Recombinant human ULBP-2 protein | NKMAX ATGP1592 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human ULBP-2 protein

catalog :

ATGP1592

quantity :

20 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human ULBP-2 protein

Domain :

26-216aa

Catalog number (SKU) :

ATGP1592

NCBI :

NP_079493

Description :

uLBP2, also known as NKG2D ligand 2, belongs to the MHC class I family. This protein is ligand for the NKG2D receptor, together with at least uLBP1 and uLBP3. uLBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of uLBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein uL16. The interaction with uL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. uL16 also causes uLBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. Recombinant human uLBP2 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Alternative Names :

UL16 binding protein 2, ALCAN-alpha, NKG2D ligand 2, N2DL-2, NKG2DL2, Retinoic acid early transcript 1H, RAET1H, N2DL2

Concentration :

1mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 30% glycerol, 2M urea, 0.2M NaCl, 2mM DTT

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Cosman D., et al. (2001) Immunity. 14:123-133;; Dunn C., et al. (2003) J. Exp. Med. 197:1427-1439

Purity :

> 85% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

24.3 kDa (216aa)

Amino Acid Sequence :

MGSSHHHHHH SSGLVPRGSH MGSHMGRADP HSLCYDITVI PKFRPGPRWC AVQGQVDEKT FLHYDCGNKT VTPVSPLGKK LNVTTAWKAQ NPVLREVVDI LTEQLRDIQL ENYTPKEPLT LQARMSCEQK AEGHSSGSWQ FSFDGQIFLL FDSEKRMWTT VHPGARKMKE KWENDKVVAM SFHYFSMGDC IGWLEDFLMG MDSTLEPSAG APLAMS

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

Q9BZM5

Internal Search Terms :

ULBP2, NKG2D ligand 2, N2DL2, RAET1H,ATGP1592-10ug,ATGP1592-20ug,ATGP1592-50ug,ATGP1592-100ug,ATGP1592-250ug,ATGP1592-500ug,ATGP1592-1mg,ATGP1592-10,ATGP1592-20,ATGP1592-50,ATGP1592-100,ATGP1592-250,ATGP1592-500,ATGP1592-1

more info or order :

NKMAX product webpage