product summary
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company name :
NKMAX
product type :
protein
product name :
Recombinant human HAAO protein
catalog :
ATGP1559
quantity :
10 ug
price :
80 USD
more info or order :
product information
Product Type :
Proteins
Item Name :
Recombinant human HAAO protein
Domain :
1-286aa
Catalog number (SKU) :
ATGP1559
NCBI :
NP_036337
Description :
HAAO is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. This protein catalyzes the synthesis of quinolinic acid (QuIN) from 3-hydroxyanthranilic acid. QuIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QuIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QuIN. Recombinant human HAAO protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Alternative Names :
3-hydroxyanthranilate 34-dioxygenase, 3-hydroxyanthranilate 3,4-dioxygenase, 3-HAO, HAO
Concentration :
0.5mg/ml (determined by BCA assay)
Formulation :
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Storage :
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
General References :
Malherbe P., et al. (1994) J Biol Chem. 13;;269(19):13792-7.
Purity :
> 90% by SDS-PAGE
Applications :
SDS-PAGE
Antigen Species :
Human
Gene Category :
Metabolism
Molecular Weight :
35 kDa (310aa) confirmed by MALDI-TOF
Amino Acid Sequence :
MGSSHHHHHH SSGLVPRGSH MGSHMERRLG VRAWVKENRG SFQPPVCNKL MHQEQLKVMF IGGPNTRKDY HIEEGEEVFY QLEGDMVLRV LEQGKHRDVV IRQGEIFLLP ARVPHSPQRF ANTVGLVVER RRLETELDGL RYYVGDTMDV LFEKWFYCKD LGTQLAPIIQ EFFSSEQYRT GKPIPDQLLK EPPFPLSTRS IMEPMSLDAW LDSHHRELQA GTPLSLFGDT YETQVIAYGQ GSSEGLRQNV DVWLWQLEGS SVVTMGGRRL SLAPDDSLLV LAGTSYAWER TQGSVALSVT QDPACKKPLG
Tag :
His-Tag
Expression System :
E.coli
Product Type Name :
Recombinant Protein
UniProt No. :
P46952
Internal Search Terms :
HAA, 3-hydroxyanthranilate 34-dioxygenase, 3-hydroxyanthranilate 3,4-dioxygenase, 3-HAO, HAO,ATGP1559-10ug,ATGP1559-20ug,ATGP1559-50ug,ATGP1559-100ug,ATGP1559-250ug,ATGP1559-500ug,ATGP1559-1mg,ATGP1559-10,ATGP1559-20,ATGP1559-50,ATGP1559-100,ATGP1559-250,ATGP1559-500,ATGP1559-1
more info or order :
company information
NKMAX
SNUH Health Care Innovation Park 6F
172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
https://www.nkmaxbio.com172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
82-31-8017-8114
headquarters: South Korea
NKMAX Co. Ltd. is a biotech company that manufactures and supplies a unique line of quality proteins and antibodies worldwide to both researchers and retailers.