Recombinant human APP/Protease Nexin II protein | NKMAX ATGP1499 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human APP/Protease Nexin II protein

catalog :

ATGP1499

quantity :

20 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human APP/Protease Nexin II protein

Domain :

18-289aa

Catalog number (SKU) :

ATGP1499

NCBI :

NP_000475.1

Description :

APP, also known as amyloid beta A4 protein, functions as a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Recombinant human APP protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Alternative Names :

Amyloid beta A4 protein, AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, CTFgamma

Concentration :

1mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Kontush A., et al. (2001) Cell. Mol. Neurobiol. 21:299-315;; Walter M.F., et al. (2006) Biochem. Biophys. Res. Commun. 233:760-764

Purity :

> 85% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Neuroscience

Molecular Weight :

34.7 kDa (308aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

Amino Acid Sequence :

LEVP TDGNAGLLAE PQIAMFCGRL NMHMNVQNGK WDSDPSGTKT CIDTKEGILQ YCQEVYPELQ ITNVVEANQP VTIQNWCKRG RKQCKTHPHF VIPYRCLVGE FVSDALLVPD KCKFLHQERM DVCETHLHWH TVAKETCSEK STNLHDYGML LPCGIDKFRG VEFVCCPLAE ESDNVDSADA EEDDSDVWWG GADTDYADGS EDKVVEVAEE EEVAEVEEEE ADDDEDDEDG DEVEEEAEEP YEEATERTTS IATTTTTTTE SVEEVVRE

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

P05067

Internal Search Terms :

APP, Protease Nexin II,ATGP1499-10ug,ATGP1499-20ug,ATGP1499-50ug,ATGP1499-100ug,ATGP1499-250ug,ATGP1499-500ug,ATGP1499-1mg,ATGP1499-10,ATGP1499-20,ATGP1499-50,ATGP1499-100,ATGP1499-250,ATGP1499-500,ATGP1499-1

more info or order :

NKMAX product webpage