Recombinant human Bcl-10 protein | NKMAX ATGP1457 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human Bcl-10 protein

catalog :

ATGP1457

quantity :

10 ug

price :

240 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human Bcl-10 protein

Domain :

1-233aa

Catalog number (SKU) :

ATGP1457

NCBI :

NP_003912

Description :

BCL10, also known as B-cell lymphoma/leukemia 10, contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. It is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Recombinant human BCL10 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Alternative Names :

B cell CLL/lymphoma 10, BCL10, Immune signaling adaptor, CARMEN, CIPER, mE10, c-E10, CLAP

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.05M NaCl, 1mM DTT

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Rebeaud F., et al. (2008) Nat. Immunol. 9:272-281;; Yui D., et al. (2001) Oncogene. 20:4317-4323

Purity :

> 85% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Signal Transduction

Molecular Weight :

28.8 kDa (257aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

Amino Acid Sequence :

MEPTAP SLTEEDLTEV KKDALENLRV YLCEKIIAER HFDHLRAKKI LSREDTEEIS CRTSSRKRAG KLLDYLQENP KGLDTLVESI RREKTQNFLI QKITDEVLKL RNIKLEHLKG LKCSSCEPFP DGATNNLSRS NSDESNFSEK LRASTVMYHP EGESSTTPFF STNSSLNLPV LEVGRTENTI FSSTTLPRPG DPGAPPLPPD LQLEEEGTCA NSSEMFLPLR SRTVSRQ

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

O95999

Internal Search Terms :

, B cell CLL/lymphoma 10, B-cell lymphoma/leukemia 10, BCL10, CARMEN, c-E10, CIPER, CLAP, IMD37, Immune signaling adaptor, mE10, B cell lymphoma/leukemia 10, c E10, Ce10, ATGP1457-10ug, ATGP1457-20ug, ATGP1457-50ug, ATGP1457-100ug, ATGP1457-250ug, ATGP1457-500ug, ATGP1457-1mg, ATGP1457-010, ATGP1457-020, ATGP1457-050, ATGP1457-100, ATGP1457-250, ATGP1457-500, ATGP1457-01M

more info or order :

NKMAX product webpage