Recombinant human Casein kinase 2 alpha 1/CSNK2A1 protein

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human Casein kinase 2 alpha 1/CSNK2A1 protein

catalog :

ATGP1455

quantity :

20 ug

price :

105 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human Casein kinase 2 alpha 1/CSNK2A1 protein

Domain :

1-391aa

Catalog number (SKU) :

ATGP1455

NCBI :

NP_001886

Description :

CSNK2A1, also known as casein kinase II subunit alpha, are catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. It regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. CSNK2A1 may act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. Recombinant human CSNK2A1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Alternative Names :

Casein kinase 2 alpha 1, Casein kinase II subunit alpha, CK II alpha, CK2A1, Cka1, Cka2

Concentration :

1mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT, 0.1mM PMSF

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Prudent R., et al. (2010) Cancer Res. 70:9865-9874;; Deloukas P., et al. (2001) Nature. 414:865-871;;

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Cell Cycle

Molecular Weight :

47.8 kDa (416aa) confirmed by MALDI-TOF

Amino Acid Sequence :

MGSSHHHHHH SSGLVPRGSH MGSHMMSGPV PSRARVYTDV NTHRPREYWD YESHVVEWGN QDDYQLVRKL GRGKYSEVFE AINITNNEKV VVKILKPVKK KKIKREIKIL ENLRGGPNII TLADIVKDPV SRTPALVFEH VNNTDFKQLY QTLTDYDIRF YMYEILKALD YCHSMGIMHR DVKPHNVMID HEHRKLRLID WGLAEFYHPG QEYNVRVASR YFKGPELLVD YQMYDYSLDM WSLGCMLASM IFRKEPFFHG HDNYDQLVRI AKVLGTEDLY DYIDKYNIEL DPRFNDILGR HSRKRWERFV HSENQHLVSP EALDFLDKLL RYDHQSRLTA REAMEHPYFY TVVKDQARMG SSSMPGGSTP VSSANMMSGI SSVPTPSPLG PLAGSPVIAA ANPLGMPVPA AAGAQQ

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

P68400

Internal Search Terms :

Casein Kinase2 a, Casein kinase II subunit alpha, CK2A1, CKII,ATGP1455-10ug,ATGP1455-20ug,ATGP1455-50ug,ATGP1455-100ug,ATGP1455-250ug,ATGP1455-500ug,ATGP1455-1mg,ATGP1455-10,ATGP1455-20,ATGP1455-50,ATGP1455-100,ATGP1455-250,ATGP1455-500,ATGP1455-1

References with this Product :

Yoo JY, et al. Nuclear hormone receptor corepressor promotes esophageal cancer cell invasion by transcriptional repression of interferon-γ-inducible protein 10 in a casein kinase 2-dependent manner. (Mol Biol Cell. 2012){https://pubmed.ncbi.nlm.nih.gov/22675025/};;Yoo JY, et al. CK2-NCoR signaling cascade promotes prostate tumorigenesis. (Oncotarget. 2013){https://pubmed.ncbi.nlm.nih.gov/23669876/};;Stakkestad Ø, et al. Phosphorylation Modulates Ameloblastin Self-assembly and Ca 2+ Binding. (Front Physiol. 2017){https://pubmed.ncbi.nlm.nih.gov/28798693/};;Ko H, et al. Phosphorylation-dependent stabilization of MZF1 upregulates N-cadherin expression during protein kinase CK2-mediated epithelial-mesenchymal transition. (Oncogenesis. 2018){https://pubmed.ncbi.nlm.nih.gov/29540671/}

more info or order :

NKMAX product webpage