Recombinant human HMBS protein | NKMAX ATGP1433 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human HMBS protein

catalog :

ATGP1433

quantity :

20 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human HMBS protein

Domain :

1-361aa

Catalog number (SKU) :

ATGP1433

NCBI :

NP_000181

Description :

Porphobilinogen deaminase, also known as HMBS, is a member of the hydroxymethylbilane synthase superfamily. It is a cytoplasmic enzyme found in the heme synthesis pathway. Deficiency of HMBS causes errors in pyrrole metabolism which in turn leads to an inherited autosomal disorder called acute intermittent porphyria (AIP) which is characterized by acute attacks of neurological dysfunctions with hypertension, tachycardia, peripheral neurologic disturbances, abdominal pain and excessive amounts of aminolevulinic acid and porphobilinogen in the urine. Recombinant human HMBS protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

Porphobilinogen deaminase, PBG-D, PBGD, PORC, uPS

Concentration :

1mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 0.1M NaCl

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Schneider Yin X., et al. (2004) J Inherit Metab Dis. 625-631:471-474.;; Sheppard L., et al. (1995) Paediatr Anaesth. 15:426-428.;;

Purity :

> 95% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Metabolism

Molecular Weight :

41.9 kDa (385aa) confirmed by MALDI-TOF

Amino Acid Sequence :

MGSSHHHHHH SSGLVPRGSH MGSHMSGNGN AAATAEENSP KMRVIRVGTR KSQLARIQTD SVVATLKASY PGLQFEIIAM STTGDKILDT ALSKIGEKSL FTKELEHALE KNEVDLVVHS LKDLPTVLPP GFTIGAICKR ENPHDAVVFH PKFVGKTLET LPEKSVVGTS SLRRAAQLQR KFPHLEFRSI RGNLNTRLRK LDEQQEFSAI ILATAGLQRM GWHNRVGQIL HPEECMYAVG QGALGVEVRA KDQDILDLVG VLHDPETLLR CIAERAFLRH LEGGCSVPVA VHTAMKDGQL YLTGGVWSLD GSDSIQETMQ ATIHVPAQHE DGPEDDPQLV GITARNIPRG PQLAAQNLGI SLANLLLSKG AKNILDVARQ LNDAH

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

P08397

Internal Search Terms :

HMBS, Porphobilinogen deaminase, PBG-D, PBGD, PORC, uPS,ATGP1433-10ug,ATGP1433-20ug,ATGP1433-50ug,ATGP1433-100ug,ATGP1433-250ug,ATGP1433-500ug,ATGP1433-1mg,ATGP1433-10,ATGP1433-20,ATGP1433-50,ATGP1433-100,ATGP1433-250,ATGP1433-500,ATGP1433-1

more info or order :

NKMAX product webpage