protein

Recombinant human DCTPP1 protein

ATGP1381

10 ug

80 USD

Recombinant human DCTPP1 protein

1-170aa

ATGP1381

NP_077001

DCTPP1, also known as dCTP pyrophosphatase 1, contains an epilepsy-associated repeat (EAR) domain that is predicted to participate in protein-protein interactions, most likely involved in ligand recognition. This protein functions to hydrolyze abnormal nucleotide triphosphates (NTPs) in cancer cells that, if unregulated, could be incorporated into nascent DNA or RNA. Recombinant human DCTPP1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Deoxycytidine-triphosphatase 1, dCTPase 1, dCTP pyrophosphatase 1, CDA03, RS21C6, XTP3TPA

0.5mg/ml (determined by Bradford assay)

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.1M NaCl

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Moroz O.V. et al. (2005) J. Mol. Biol. 347: 243-255.;; Rual J.F. et al. (2005) Nature 437:1173-1178.

> 90% by SDS-PAGE

SDS-PAGE

Human

Enzymes & Proteases

21.2 kDa (194aa) confirmed by MALDI-TOF

MGSSHHHHHH SSGLVPRGSH MGSHMSVAGG EIRGDTGGED TAAPGRFSFS PEPTLEDIRR LHAEFAAERD WEQFHQPRNL LLALVGEVGE LAELFQWKTD GEPGPQGWSP RERAALQEEL SDVLIYLVAL AARCRVDLPL AVLSKMDINR RRYPAHLARS SSRKYTELPH GAISEDQAVG PADIPCDSTG QTST

His-Tag

E.coli

Recombinant Protein

Q9H773

DCTPP1, dCTP pyrophosphatase 1, CDA03, RS21C6, XTP3TPA,ATGP1381-10ug,ATGP1381-20ug,ATGP1381-50ug,ATGP1381-100ug,ATGP1381-250ug,ATGP1381-500ug,ATGP1381-1mg,ATGP1381-10,ATGP1381-20,ATGP1381-50,ATGP1381-100,ATGP1381-250,ATGP1381-500,ATGP1381-1

Kawamura T, et al. Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival. (Sci Rep. 2016){https://pubmed.ncbi.nlm.nih.gov/27210421/}