protein

Recombinant human GPD1L protein

ATGP1214

20 ug

80 USD

Recombinant human GPD1L protein

1-351aa

ATGP1214

NP_055956

GPD1L, also known as glycerol-3-phosphate dehydrogenase 1-like protein, converts sn-glycerol 3-phosphate to glycerone phosphate. This protein is found in the cytoplasm, associated with the plasma membrane, where it binds the sodium channel, voltage-gated, type V, alpha subunit (SCN5A). Mutations in GPD1L are the cause of sudden infant death syndrome (SIDS) and Brugada syndrome type 2, an autosomal dominant tachyarrhythmia. Recombinant human GPD1L protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Glycerol-3-phosphate dehydrogenase 1-like protein, GPD1-L

1mg/ml (determined by Bradford assay)

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 1mM DTT

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Valdivia C.R., et al. (2009) Am. J. Physiol. 297:H1446-H1452;; Van Norstrand D.W., et al. (2007) Circulation. 116:2253-2259

> 95% by SDS-PAGE

SDS-PAGE

Human

Metabolism

40.6 kDa (371aa) confirmed by MALDI-TOF

MAAAPLKVCI VGSGNWGSAV AKIIGNNVKK LQKFASTVKM WVFEETVNGR KLTDIINNDH ENVKYLPGHK LPENVVAMSN LSEAVQDADL LVFVIPHQFI HRICDEITGR VPKKALGITL IKGIDEGPEG LKLISDIIRE KMGIDISVLM GANIANEVAA EKFCETTIGS KVMENGLLFK ELLQTPNFRI TVVDDADTVE LCGALKNIVA VGAGFCDGLR CGDNTKAAVI RLGLMEMIAF ARIFCKGQVS TATFLESCGV ADLITTCYGG RNRRVAEAFA RTGKTIEELE KEMLNGQKLQ GPQTSAEVYR ILKQKGLLDK FPLFTAVYQI CYESRPVQEM LSCLQSHPEH T

His-Tag

E.coli

Recombinant Protein

Q8N335

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