protein

Recombinant human MGP protein

ATGP1198

20 ug

80 USD

Recombinant human MGP protein

20-96aa

ATGP1198

NP_000891.2

MGP, also known as Matrix Gla protein, is a protein involved in regulating calcification in the extracellular matrix, in particular in cartilage and arteries. MGP is a vitamin K-dependent protein, and contains five to six residues of Gla, a Ca2+ binding amino acid requiring vitamin K-dependent gamma carboxylase for its formation. It is found in human bone extracts, likely formed by COOH-terminal processing by carboxypeptidase B-like enzymatic activity. Recombinant human MGP protein, fused to His-tag at N-terminus, was expressed in E. coli and denatured using detergent during a conventional chromatography purification process.

Matrix Gla protein isoform 2 precursor, GIG36, MGLAP, NTI

1mg/ml (determined by Bradford assay)

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Cancela L.et al. (1990) J Biol Chem. 265: 15040-15048.;; Hale J.E.et al. (1991) J. Biol. Chem. 266: 21145-21149.

> 90% by SDS-PAGE

SDS-PAGE, Denatured

Human

Cytoskeleton

11.8 kDa (98aa)

YESHESMES YELNPFINRR NANTFISPQQ RWRAKVQERI RERSKPVHEL NREACDDYRL CERYAMVYGY NAAYNRYF

His-Tag

E.coli

Recombinant Protein

P08493

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A Taisuke, et al. The effect of HSP70 and MGP on Smad phosphorilation by BMP-2 in human dental pulp cells. (The journal of Japan Endodontic Association. 2013){https://doi.org/10.20817/jeajournal.34.1_16}