Recombinant human TPM4 protein | NKMAX ATGP0992 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human TPM4 protein

catalog :

ATGP0992

quantity :

10 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human TPM4 protein

Domain :

1-248aa

Catalog number (SKU) :

ATGP0992

NCBI :

NP_003281

Description :

TPM4 belongs to the tropomyosin family. Tropomyosins are present in virtually all eukaryotic cells (both muscle and nonmuscle), where they bind actin filaments and function to modulate actin-myosin interaction and stabilize actin filament structure. TPM4 binds to actin filaments in muscle and nonmuscle cells and plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. Recombinant human TPM4 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

Tropomyosin alpha-4 chain, Tropomyosin 4

Concentration :

1mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl.

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Lehman W., et al. (2000) J Mol Biol. 302(3):593-606. ;; Wilton SD., et al. (1996) Cytogenet Cell Genet. 72(4):294-6.

Purity :

> 85% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Cytoskeleton

Molecular Weight :

30.7 kDa (268aa) confirmed by MALDI-TOF

Amino Acid Sequence :

MGSSHHHHHH SSGLVPRGSH MAGLNSLEAV KRKIQALQQQ ADEAEDRAQG LQRELDGERE RREKAEGDVA ALNRRIQLVE EELDRAQERL ATALQKLEEA EKAADESERG MKVIENRAMK DEEKMEIQEM QLKEAKHIAE EADRKYEEVA RKLVILEGEL ERAEERAEVS ELKCGDLEEE LKNVTNNLKS LEAASEKYSE KEDKYEEEIK LLSDKLKEAE TRAEFAERTV AKLEKTIDDL EEKLAQAKEE NVGLHQTLDQ TLNELNCI

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

P67936

Internal Search Terms :

TPM4, Tropomyosin alpha-4 chain, Tropomyosin 4,ATGP0992-10ug,ATGP0992-20ug,ATGP0992-50ug,ATGP0992-100ug,ATGP0992-250ug,ATGP0992-500ug,ATGP0992-1mg,ATGP0992-10,ATGP0992-20,ATGP0992-50,ATGP0992-100,ATGP0992-250,ATGP0992-500,ATGP0992-1

References with this Product :

Karasawa R, et al. Association of Anti-TPM4 autoantibodies with vasculopathic cutaneous manifestations in juvenile dermatomyositis. (Rheumatology (Oxford). 2023){https://pubmed.ncbi.nlm.nih.gov/37144941/}

more info or order :

NKMAX product webpage