Recombinant human BPNT1 protein | NKMAX ATGP0883 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human BPNT1 protein

catalog :

ATGP0883

quantity :

10 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human BPNT1 protein

Domain :

1-308aa

Catalog number (SKU) :

ATGP0883

NCBI :

NP_006076

Description :

BPNT1, also known as BPntase, PAP phosphatase or PIP (PAP-inositol-1, 4-phosphatase), is a member of the magnesium-dependent, lithium-sensitive phosphomono-esterase superfamily. using magnesium as a cofactor, BPNT1 catalyzes the conversion of PAPS (adenosine 3'-phosphate 5' phosphosulfate) to APS (adenosine 5'-phosphosulfate) and the conversion of PAP (3' (2') -phosphoadenosine 5' phosphate) to AMP (adenosine 5'-phosphate). Expressed ubiquitously with highest levels in brain and kidney, BPNT1 is potently inhibited by lithium, a drug used for the treatment of manic depression and bipolar affective disorder, suggesting a possible role for BPNT1 in the etiology of mood disorders. Recombinant human BPNT1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

3'(2') 5'-bisphosphate nucleotidase 1, 3'(2'), 5'-bisphosphate nucleotidase 1, PIP, PAP-inositol-1,4-phosphatase

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 5mM DTT, 0.1M NaCl.

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Shaltiel G., et al. (2002) Bipolar Disord. 4(5):302-6. ;; Agam G., et al. (2003) J Psychiatr Res. 37(5):433-42.

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Neuroscience

Molecular Weight :

37.5 kDa (344aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

Amino Acid Sequence :

MASS NTVLMRLVAS AYSIAQKAGM IVRRVIAEGD LGIVEKTCAT DLQTKADRLA QMSICSSLAR KFPKLTIIGE EDLPSEEVDQ ELIEDSQWEE ILKQPCPSQY SAIKEEDLVV WVDPLDGTKE YTEGLLDNVT VLIGIAYEGK AIAGVINQPY YNYEAGPDAV LGRTIWGVLG LGAFGFQLKE VPAGKHIITT TRSHSNKLVT DCVAAMNPDA VLRVGGAGNK IIQLIEGKAS AYVFASPGCK KWDTCAPEVI LHAVGGKLTD IHGNVLQYHK DVKHMNSAGV LATLRNYDYY ASRVPESIKN ALVP

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

O95861

Internal Search Terms :

BPNT1, 3'(2') 5'-bisphosphate nucleotidase 1, 3'(2'), 5'-bisphosphate nucleotidase 1, PIP, PAP-inositol-1,4-phosphatase,ATGP0883-10ug,ATGP0883-20ug,ATGP0883-50ug,ATGP0883-100ug,ATGP0883-250ug,ATGP0883-500ug,ATGP0883-1mg,ATGP0883-10,ATGP0883-20,ATGP0883-50,ATGP0883-100,ATGP0883-250,ATGP0883-500,ATGP0883-1

more info or order :

NKMAX product webpage