Recombinant human REF-1/APEX1 protein | NKMAX ATGP0881 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human REF-1/APEX1 protein

catalog :

ATGP0881

quantity :

10 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human REF-1/APEX1 protein

Domain :

1-318aa

Catalog number (SKU) :

ATGP0881

NCBI :

AAH19291.1

Description :

APEX1, also known as REF1 or APE1 (Apurinic / apyrimidinic endonuclease), is responsible for the incision of DNA basic sites during base excision repair. It has also been shown to stimulate the DNA binding activity of numerous transcription factors that are involved in cancer promotion and progression. APEX1 is part of the cellular response to oxidative stress and protects cells from the genotoxic and cytotoxic effect of oxidizing agents. Recombinant human APEX1 protein, fused to T7-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

Apurinic/apyrimidinic endodeoxyribonuclease 1, APEX nuclease, APEN, multifunctional DNA repair enzyme 1, DNA-(apurinic or apyrimidinic site) endonuclease, AP endonuclease 1, APE-1, Redox factor-1, APE, APE1, APEX, APX, HAP1, REF1

Concentration :

1mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 2mM DTT, 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Hinz AK., et al. (2010) J Biol Chem. 285(37):28683-90.;; Wu HH., et al. (2010) Oncogene. 29(30):4330-40.

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Enzymes & Proteases

Molecular Weight :

36.9 kDa (332aa) confirmed by MALDI-TOF

Amino Acid Sequence :

MPKRGK KGAVAEDGDE LRTEPEAKKS KTAAKKNDKE AAGEGPALYE DPPDQKTSPS GKPATLKICS WNVDGLRAWI KKKGLDWVKE EAPDILCLQE TKCSENKLPA ELQELPGLSH QYWSAPSDKE GYSGVGLLSR QCPLKVSYGI GEEEHDQEGR VIVAEFDSFV LVTAYVPNAG RGLVRLEYRQ RWDEAFRKFL KGLASRKPLV LCGDLNVAHE EIDLRNPKGN KKNAGFTPQE RQGFGELLQA VPLADSFRHL YPNTPYAYTF WTYMMNARSK NVGWRLDYFL LSHSLLPALC DSKIRSKALG SDHCPITLYL AL

Tag :

T7-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

P27695

Internal Search Terms :

APE, APEX nuclease (multifunctional DNA repair enzyme) 1, APE, APE1, APEN, APX, HAP1, REF-1, REF1,ATGP0881-10ug,ATGP0881-20ug,ATGP0881-50ug,ATGP0881-100ug,ATGP0881-250ug,ATGP0881-500ug,ATGP0881-1mg,ATGP0881-10,ATGP0881-20,ATGP0881-50,ATGP0881-100,ATGP0881-250,ATGP0881-500,ATGP0881-1

more info or order :

NKMAX product webpage