Recombinant human BPHL protein | NKMAX ATGP0870 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human BPHL protein

catalog :

ATGP0870

quantity :

20 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human BPHL protein

Domain :

38-291aa

Catalog number (SKU) :

ATGP0870

NCBI :

NP_004323

Description :

BPHL is a Serine hydrolase which Belongs to the AB hydrolase superfamily. This family catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. This protein is expressed at high levels in liver and kidney and at lower levels in heart, intestine and skeletal muscle. It plays a role in detoxification processes. BPHL is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. Recombinant human BPHL protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

Valacyclovir hydrolase, BPH-RP, MCNAA, VACVASE

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT, 50mM NaCl

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Lai L., et al. (2008) J. Biol. Chem. 283:9318-9327.;; Puente X.S., et al. (1995) J. Biol. Chem. 270:12926-12932;;

Purity :

> 95% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Metabolism

Molecular Weight :

31.1 kDa (275aa) confirmed by MALDI-TOF

Amino Acid Sequence :

MGSSHHHHHH SSGLVPRGSH MSVTSAKVAV NGVQLHYQQT GEGDHAVLLL PGMLGSGETD FGPQLKNLNK KLFTVVAWDP RGYGHSRPPD RDFPADFFER DAKDAVDLMK ALKFKKVSLL GWSDGGITAL IAAAKYPSYI HKMVIWGANA YVTDEDSMIY EGIRDVSKWS ERTRKPLEAL YGYDYFARTC EKWVDGIRQF KHLPDGNICR HLLPRVQCPA LIVHGEKDPL VPRFHADFIH KHVKGSRLHL MPEGKHNLHL RFADEFNKLA EDFLQ

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

Q86WA6

Internal Search Terms :

BPHL, Valacyclovir hydrolase, BPH-RP, MCNAA, VACVASE,ATGP0870-10ug,ATGP0870-20ug,ATGP0870-50ug,ATGP0870-100ug,ATGP0870-250ug,ATGP0870-500ug,ATGP0870-1mg,ATGP0870-10,ATGP0870-20,ATGP0870-50,ATGP0870-100,ATGP0870-250,ATGP0870-500,ATGP0870-1

more info or order :

NKMAX product webpage