Recombinant human CRKL protein | NKMAX ATGP0857 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human CRKL protein

catalog :

ATGP0857

quantity :

20 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human CRKL protein

Domain :

1-303aa

Catalog number (SKU) :

ATGP0857

NCBI :

NP_005198.1

Description :

CRKL is a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JuN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substitutete of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and has oncogenic potential. Recombinant human CRKL protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

CRK like proto-oncogene, Adaptor protein, V-crk avian sarcoma virus CT10 oncogene homolog-like

Concentration :

1mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl.

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Arai A., et al. (2001) J Biol Chem. 276(35):33282-90. ;; Senechal K., et al. (1996) J Biol Chem. 271(38):23255-61.;;

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Cancer

Molecular Weight :

35.9 kDa (323aa) confirmed by MALDI-TOF

Amino Acid Sequence :

MSSARFDSSD RSAWYMGPVS RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL SVSENSRVSH YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE PAPRYPSPPM GSVSAPNLPT AEDNLEYVRT LYDFPGNDAE DLPFKKGEIL VIIEKPEEQW WSARNKDGRV GMIPVPYVEK LVRSSPHGKH GNRNSNSYGI PEPAHAYAQP QTTTPLPAVS GSPGAAITPL PSTQNGPVFA KAIQKRVPCA YDKTALALEV GDIVKVTRMN INGQWEGEVN GRKGLFPFTH VKIFDPQNPD ENE

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

P46109

Internal Search Terms :

CrkL, Crk-like protein,ATGP0857-10ug,ATGP0857-20ug,ATGP0857-50ug,ATGP0857-100ug,ATGP0857-250ug,ATGP0857-500ug,ATGP0857-1mg,ATGP0857-10,ATGP0857-20,ATGP0857-50,ATGP0857-100,ATGP0857-250,ATGP0857-500,ATGP0857-1

more info or order :

NKMAX product webpage