product summary
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company name :
NKMAX
product type :
protein
product name :
Recombinant human Sirtuin 2/SIRT2 protein
catalog :
ATGP0803
quantity :
10 ug
price :
240 USD
more info or order :
product information
Product Type :
Proteins
Item Name :
Recombinant human Sirtuin 2/SIRT2 protein
Domain :
1-352aa
Catalog number (SKU) :
ATGP0803
NCBI :
NP_085096
Description :
SIRT2 (NAD-dependent deacetylase sirtuin-2) is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. SIRT2 is a NAD-dependent deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Recombinant human SIRT2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Alternative Names :
NAD-dependent protein deacetylase sirtuin-2, NAD-dependent protein defatty-acylase sirtuin-2, Regulatory protein SIR2 homolog 2, SIR2-like protein 2, SIR2L, SIR2L2, Sirtuin, Silent mating type information regulation 2 homolog 2 (S. cerevisiae) cerevisiae)
Concentration :
0.25mg/ml (determined by Bradford assay)
Formulation :
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 30% glycerol, 2mM DTT, 200mM NaCl, 0.5mM EDTA
Storage :
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
General References :
North B.J., et al. (2003) Mol. Cell 11:437-444;; Dryden S.C., et al. (2003) Mol. Cell. Biol. 23:3173-3185
Purity :
> 90% by SDS-PAGE
Applications :
SDS-PAGE
Antigen Species :
Human
Gene Category :
Cell Cycle
Molecular Weight :
41.6 kDa (372aa) confirmed by MALDI-TOF
Amino Acid Sequence :
MDFLRNLFSQ TLSLGSQKER LLDELTLEGV ARYMQSERCR RVICLVGAGI STSAGIPDFR SPSTGLYDNL EKYHLPYPEA IFEISYFKKH PEPFFALAKE LYPGQFKPTI CHYFMRLLKD KGLLLRCYTQ NIDTLERIAG LEQEDLVEAH GTFYTSHCVS ASCRHEYPLS WMKEKIFSEV TPKCEDCQSL VKPDIVFFGE SLPARFFSCM QSDFLKVDLL LVMGTSLQVQ PFASLISKAP LSTPRLLINK EKAGQSDPFL GMIMGLGGGM DFDSKKAYRD VAWLGECDQG CLALAELLGW KKELEDLVRR EHASIDAQSG AGVPNPSTSA SPKKSPPPAK DEARTTEREK PQ
Tag :
His-Tag
Expression System :
E.coli
Product Type Name :
Recombinant Protein
UniProt No. :
Q8IXJ6
Internal Search Terms :
Sirtuin2, SIRT2, NAD-dependent deacetylase sirtuin-2, SIR2, SIR2L, SIR2L2,ATGP0803-10ug,ATGP0803-20ug,ATGP0803-50ug,ATGP0803-100ug,ATGP0803-250ug,ATGP0803-500ug,ATGP0803-1mg,ATGP0803-10,ATGP0803-20,ATGP0803-50,ATGP0803-100,ATGP0803-250,ATGP0803-500,ATGP0803-1
References with this Product :
Kawaguchi M, et al. A Fluorescent Probe for Imaging Sirtuin Activity in Living Cells, Based on One-Step Cleavage of the Dabcyl Quencher. (Chembiochem. 2016){https://pubmed.ncbi.nlm.nih.gov/27542094/};;Kawaguchi M, et al. Development of Peptide-Based Sirtuin Defatty-Acylase Inhibitors Identified by the Fluorescence Probe, SFP3, That Can Efficiently Measure Defatty-Acylase Activity of Sirtuin. (J Med Chem. 2019 ){https://pubmed.ncbi.nlm.nih.gov/31117516/}
more info or order :
company information
NKMAX
SNUH Health Care Innovation Park 6F
172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
https://www.nkmaxbio.com
82-31-8017-8114
headquarters: South Korea
NKMAX Co. Ltd. is a biotech company that manufactures and supplies a unique line of quality proteins and antibodies worldwide to both researchers and retailers.