protein

Recombinant human VAP-B protein

ATGP0800

20 ug

80 USD

Recombinant human VAP-B protein

1-222aa

ATGP0800

NP_004729

VAPB, also known as vesicle-associated membrane protein (VAMP) -associated protein B, is a type IV transmembrane protein and member of the VAP family of proteins. This protein may play a role in vesicle trafficking. It is found in plasma and intracellular vesicle membranes as a homodimer and heterodimer with VAPA, and interacts with VAMP1 and VAMP2. Defects in VAPB are a cause of amyotrophic lateral sclerosis type 8 and spinal muscular atrophy autosomal dominant Finkel type. Recombinant human VAPB protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Vesicle-associated membrane protein-associated protein B/C, ALS8, VAMP-B, VAMP-C, VAP-B, VAP-C

1mg/ml (determined by Bradford assay)

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Nishimura AL, et al. (2004), Am J Hum Genet., 75(5):822-31.;; Hamamoto I., et al. (2005). J Virol., 79(21):13473-82.

> 90% by SDS-PAGE

SDS-PAGE

Human

Neuroscience

27.1 kDa (242aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

MGSSHHHHHH SSGLVPRGSH MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTAPR RYCVRPNSGI IDAGASINVS VMLQPFDYDP NEKSKHKFMV QSMFAPTDTS DMEAVWKEAK PEDLMDSKLR CVFELPAEND KPHDVEINKI ISTTASKTET PIVSKSLSSS LDDTEVKKVM EECKRLQGEV QRLREENKQF KEEDGLRMRK TVQSNSPISA LAPTGKEEGL ST

His-Tag

E.coli

Recombinant Protein

O95292

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