Recombinant human CCS protein | NKMAX ATGP0715 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human CCS protein

catalog :

ATGP0715

quantity :

20 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human CCS protein

Domain :

1-274aa

Catalog number (SKU) :

ATGP0715

NCBI :

NP_005116

Description :

CCS is essential for the incorporation of copper into SOD-1, and therefore is necessary for its enzymatic activity. CCS prevents copper ions from binding to intracellular copper scavengers and provides the SOD-1 enzyme with the necessary copper cofactor. CCS escorts copper only to SOD-1 and fails to deliver copper to proteins in the mitochondria, nucleus or secretory pathway. While many tissues express CCS, the chaperone is most abundant in the kidney, liver and Purkinje cells in the neuropil of the central nervous system. Recombinant human CCS protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

Copper chaperone for superoxide dismutase

Concentration :

1mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl 1mM DTT, 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Romerius P., et al. (2010) Clin Cancer Res. 16(15):3843-50.;; Seetharaman SV., et al. (2010) Biochemistry. 49(27):5714-25.;;

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Cancer

Molecular Weight :

31.2 kDa (294aa) confirmed by MALDI-TOF

Amino Acid Sequence :

MASDSGNQGT LCTLEFAVQM TCQSCVDAVR KSLQGVAGVQ DVEVHLEDQM VLVHTTLPSQ EVQALLEGTG RQAVLKGMGS GQLQNLGAAV AILGGPGTVQ GVVRFLQLTP ERCLIEGTID GLEPGLHGLH VHQYGDLTNN CNSCGNHFNP DGASHGGPQD SDRHRGDLGN VRADADGRAI FRMEDEQLKV WDVIGRSLII DEGEDDLGRG GHPLSKITGN SGERLACGII ARSAGLFQNP KQICSCDGLT IWEERGRPIA GKGRKESAQP PAHL

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

O14618

Internal Search Terms :

CCS, Copper chaperone for superoxide dismutase,ATGP0715-10ug,ATGP0715-20ug,ATGP0715-50ug,ATGP0715-100ug,ATGP0715-250ug,ATGP0715-500ug,ATGP0715-1mg,ATGP0715-10,ATGP0715-20,ATGP0715-50,ATGP0715-100,ATGP0715-250,ATGP0715-500,ATGP0715-1

more info or order :

NKMAX product webpage