protein

Recombinant human CBFB protein

ATGP0667

10 ug

80 USD

Recombinant human CBFB protein

1-182aa

ATGP0667

NP_001746

CBFB, also known as PEBP2B, is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e. g., RuNX1) and osteogenesis (e. g., RuNX2). This protein is a non-DNA binding regulatory subunit and it allosterically enhances DNA binding by alpha subunit. Recombinant human CBFB protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Core-binding factor beta subunit, PEBP2B (polyomavirus enhancer binding protein b), PEA2, CBF-beta, Core-binding factor, beta subunit

0.5mg/ml (determined by Bradford assay)

Liquid in. 20mM MES buffer (pH 6.0) containing 0.1mM PMSF, 10% glycerol

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Speck NA., et al. (2009) Blood. 113(13):3070-9.;; Ito Y., et al. (2008) Blood. 112(9):3777-87.;;

> 85% by SDS-PAGE

SDS-PAGE

Human

Epigenomics (Transcription & Translation)

23.6 kDa (202aa) confirmed by MALDI-TOF

MPRVVPDQRS KFENEEFFRK LSRECEIKYT GFRDRPHEER QARFQNACRD GRSEIAFVAT GTNLSLQFFP ASWQGEQRQT PSREYVDLER EAGKVYLKAP MILNGVCVIW KGWIDLQRLD GMGCLEFDEE RAQQEDALAQ QAFEEARRRT REFEDRDRSH REEMEVRVSQ LLAVTGKKTT RP

His-Tag

E.coli

Recombinant Protein

Q13951

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