Recombinant human p62/SQSTM1 protein | NKMAX ATGP0532 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human p62/SQSTM1 protein

catalog :

ATGP0532

quantity :

20 ug

price :

70 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human p62/SQSTM1 protein

Domain :

1-356aa

Catalog number (SKU) :

ATGP0532

NCBI :

NP_001135771

Description :

SQSTM1 is an adapter protein which binds ubiquitin and regulates signaling cascades through ubiquitination. It may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 and play a role in titin/TTN downstream signaling in muscle cells. This protein also may be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels. Mutations in the ubiquitin-associated (uBA) domain of the sequestosome 1 protein commonly cause Paget's disease since the uBA is necessary for aggregate sequestration and cell survival. Recombinant SQSTM1 protein, fused to His-tag at C-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

Sequestosome 1, A170, OSIL, p60, p62, p62B, PDB3, ZIP3, Sequestosome 1 EBI 3 associated protein of 60 kDa, ZIP, ZIP 3, EBI3 associated protein of 60 kDa, EBIAP, MGC127197, ORCA.M530, OSF-6, Osi, Oxidative stress induced like, Paget disease of bone 3, PDB 3, Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa, Phosphotyrosine independent ligand for the Lck SH2 domain p62, PKC-zeta-interacting protein, Protein kinase C-zeta-interacting protein, SQSTM 1, STAP, STONE14, ubiquitin binding protein p62,

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 1mM DTT

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Falchetti A., et al. (2004) J Bone Miner Res. 19(6):1013-7.

Purity :

> 85% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Signal Transduction

Molecular Weight :

39.7 kDa (364aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

Amino Acid Sequence :

MAMSYVKDDI FRIYIKEKKE CRRDHRPPCA QEAPRNMVHP NVICDGCNGP VVGTRYKCSV CPDYDLCSVC EGKGLHRGHT KLAFPSPFGH LSEGFSHSRW LRKVKHGHFG WPGWEMGPPG NWSPRPPRAG EARPGPTAES ASGPSEDPSV NFLKNVGESV AAALSPLGIE VDIDVEHGGK RSRLTPVSPE SSSTEEKSSS QPSSCCSDPS KPGGNVEGAT QSLAEQMRKI ALESEGRPEE QMESDNCSGG DDDWTHLSSK EVDPSTGELQ SLQMPESEGP SSLDPSQEGP TGLKEAALYP HLPPEADPRL IESLSQMLSM GFSDEGGWLT RLLQTKNYDI GAALDTIQYS KHPPPL

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

Q13501

Internal Search Terms :

p62, SQSTM1,ATGP0532-10ug,ATGP0532-20ug,ATGP0532-50ug,ATGP0532-100ug,ATGP0532-250ug,ATGP0532-500ug,ATGP0532-1mg,ATGP0532-10,ATGP0532-20,ATGP0532-50,ATGP0532-100,ATGP0532-250,ATGP0532-500,ATGP0532-1

more info or order :

NKMAX product webpage