product summary
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company name :
NKMAX
product type :
protein
product name :
Recombinant human Aldo-keto reductase 7A2/AKR7A2 protein
catalog :
ATGP0478
quantity :
20 ug
price :
105 USD
more info or order :
product information
Product Type :
Proteins
Item Name :
Recombinant human Aldo-keto reductase 7A2/AKR7A2 protein
Domain :
1-359aa
Catalog number (SKU) :
ATGP0478
NCBI :
NP_003680
Description :
Aldo-keto reductases, such as AKR7A2, are involved in the detoxification of aldehydes and ketones. This protein can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the nonbinding AFB1 dialcohol. It may be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Also, it has been proposed previously to catalyze the NADPH-dependent reduction of succinic semialdehyde (SSA) to gamma-Hydroxybutyrate in human brain. Recombinant AKR7A2 protein was expressed in E. coli and purified by using conventional chromatography techniques.
Alternative Names :
Aldo-keto reductase family 7 member A2, Aflatoxin B1 aldehyde reductase member 2, AFB1 aldehyde reductase 1 (AFB1-AR 1), Aldoketoreductase 7, Succinic semialdehyde reductase (SSA reductase), AFAR, AFAR1, AKR7
Concentration :
0.5mg/ml (determined by Bradford assay)
Formulation :
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol
Storage :
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
General References :
Bodreddigari S., et al. (2008) Chem Res Toxicol. 21(5):1134-42.;; Malaspina P., et al. (2009) Hum Genomics. 3(2):106-20.
Purity :
> 90% by SDS-PAGE
Bioactivity Comment Only :
Specific activity is > 1000pmol/min/ug, and is defined as the amount of enzyme that catalyze the reduction 1.0pmole of 1,2-Naphthoquinone presence of NADPH per minute at pH 7.0 at 25C.
Applications :
SDS-PAGE, Enzyme Activity
Antigen Species :
Human
Gene Category :
Redox Proteins
Molecular Weight :
44 kDa (398aa) confirmed by MALDI-TOF
Bioactivity Comment and Pics :
Specific activity is > 1000 pmol/min/ug, and is defined as the amount of enzyme that catalyze the reduction 1.0 pmole of 1,2-Naphthoquinone presence of NADPH per minute at pH 7.0 at 25C.
Amino Acid Sequence :
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSELEM LSAASRVVSR AAVHCALRSP PPEARALAMS RPPPPRVASV LGTMEMGRRM DAPASAAAVR AFLERGHTEL DTAFMYSDGQ SETILGGLGL GLGGGDCRVK IATKANPWDG KSLKPDSVRS QLETSLKRLQ CPQVDLFYLH APDHGTPVEE TLHACQRLHQ EGKFVELGLS NYASWEVAEI CTLCKSNGWI LPTVYQGMYN ATTRQVETEL FPCLRHFGLR FYAYNPLAGG LLTGKYKYED KDGKQPVGRF FGNSWAETYR NRFWKEHHFE AIALVEKALQ AAYGASAPSV TSAALRWMYH HSQLQGAHGD AVILGMSSLE QLEQNLAATE EGPLEPAVVD AFNQAWHLVA HECPNYFR
Tag :
His-Tag
Expression System :
E.coli
Product Type Name :
Recombinant Protein
UniProt No. :
O43488
Internal Search Terms :
Aflatoxin B1 aldehyde reductase member2, AKR7A2, aldo-keto reductase family 7 member A2, Aflatoxin B1 aldehyde reductase member 2, AFAR, AFAR1, AFB1-AR1, AKR7, aldo-keto reductase family 7, member A2 AFB1 AR1, AFB1AR1, aflatoxin aldehyde reductase, aflatoxin beta1 aldehyde reductase, Aiar, aldo keto reductase family 7, aldo keto reductase family 7, member A2, aldoketoreductase 7.,ATGP0478-10ug,ATGP0478-20ug,ATGP0478-50ug,ATGP0478-100ug,ATGP0478-250ug,ATGP0478-500ug,ATGP0478-1mg,ATGP0478-10,ATGP0478-20,ATGP0478-50,ATGP0478-100,ATGP0478-250,ATGP0478-500,ATGP0478-1
more info or order :
company information
NKMAX
SNUH Health Care Innovation Park 6F
172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
https://www.nkmaxbio.com172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
82-31-8017-8114
headquarters: South Korea
NKMAX Co. Ltd. is a biotech company that manufactures and supplies a unique line of quality proteins and antibodies worldwide to both researchers and retailers.