protein

Recombinant human Transthyretin/Prealbumin protein

ATGP0456

20 ug

70 USD

Recombinant human Transthyretin/Prealbumin protein

21-147aa

ATGP0456

NP_000362.1

Prealbumin, also known Transthyretin, is a tetrameric human plasma protein that is synthesized mainly in the liver. This protein transports the thyroid hormone thyroxine (T4) and retinol (Vitamin A). It is the best indicator of protein-energy malnutrition because it has a circulating half life of 2 days and responds rapidly to changes in nutritional status. Also point-mutations of its gene are known to be associated with the amyloid diseases senile systemic amyloidosis (SSA), familial amyloid polyneuropathy (FAP), and familial amyloid cardiomyopathy (FAC). Recombinant human Prealbumin was expressed in E. coli and purified by using conventional chromatography.

TTR, Transthyretin, TBPA, ATTR, PALB, Amyloid polyneuropathy, Amyloidosis I, Dysprealbuminemic euthyroidal hyperthyroxinemia, Dystransthyretinemic hyperthyroxinemia, HsT2651, Prealbumin amyloidosis type I, Senile systemic amyloidosis, TTR protein.

1mg/ml (determined by Bradford assay)

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Ando Y., et al. (2009) Rinsho Byori. 57(3):228-35.;; Shenkin A., et al. (2006) Clin Chem. 52(12):2177-9.;;

> 90% by SDS-PAGE

SDS-PAGE

Human

Neuroscience

N- terminal Sequence Analysis: Met-Gly-Pro-Thr-Gly

13.8 kDa (128aa) confirmed by MALDI-TOF

< 1 EU per 1ug of protein (determined by LAL method)

MGPTGTGESK CPLMVKVLDA VRGSPAINVA VHVFRKAADD TWEPFASGKT SESGELHGLT TEEEFVEGIY KVEIDTKSYW KALGISPFHE HAEVVFTAND SGPRRYTIAA LLSPYSYSTT AVVTNPKE

Non-Tagged

E.coli

Recombinant Protein

P02766

Transthyretin, Prealbumin, TTR, Transthyretin, TBPA, ATTR, PALB, Amyloid polyneuropathy, Amyloidosis I, Dysprealbuminemic euthyroidal hyperthyroxinemia, Dystransthyretinemic hyperthyroxinemia, HsT2651, Prealbumin amyloidosis type I, Senile systemic amyloidosis, TTR protein.,ATGP0456-10ug,ATGP0456-20ug,ATGP0456-50ug,ATGP0456-100ug,ATGP0456-250ug,ATGP0456-500ug,ATGP0456-1mg,ATGP0456-10,ATGP0456-20,ATGP0456-50,ATGP0456-100,ATGP0456-250,ATGP0456-500,ATGP0456-1

Abdirama D, et al. Nuclear antigen-reactive CD4 + T cells expand in active systemic lupus erythematosus, produce effector cytokines, and invade the kidneys. (Kidney Int. 2021){https://pubmed.ncbi.nlm.nih.gov/32592813/}