Recombinant human Aldo-keto reductase 1A1/AKR1A1 protein

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human Aldo-keto reductase 1A1/AKR1A1 protein

catalog :

ATGP0433

quantity :

20 ug

price :

70 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human Aldo-keto reductase 1A1/AKR1A1 protein

Domain :

1-325aa

Catalog number (SKU) :

ATGP0433

NCBI :

NP_006057

Description :

Alcohol dehydrogenase [NADP+] (AKR1A1) is a member of the aldo/keto reductase superfamily and catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. This protein is closely related (65% identity) to aldose reductase, an enzyme involved in the pathogenesis of some diabetic and galactosemic complications. It plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAuN). Recombinant human Alcohol dehydrogenase was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

Dihydrodiol dehydrogenase 3, DD3, ARM, ALR, ALDR1, aldo-keto reductase family 1 member A1 (aldehyde reductase), Aldehyde reductase, Alcohol dehydrogenase [NADP+], Alcohol dehydrogenase, AKR1A1

Concentration :

1mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 50mM NaCl, 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Bohren KM., et al. (1989) J Biol Chem. 264(16): 9547-51.;; Vander Jaqt DL., et al. (1990) J Biol Chem. 265(19):10912-8.;;

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Redox Proteins

Molecular Weight :

36.5 kDa (325aa) confirmed by MALDI-TOF

Amino Acid Sequence :

MAASCVLLHT GQKMPLIGLG TWKSEPGQVK AAVKYALSVG YRHIDCAAIY GNEPEIGEAL KEDVGPGKAV PREELFVTSK LWNTKHHPED VEPALRKTLA DLQLEYLDLY LMHWPYAFER GDNPFPKNAD GTICYDSTHY KETWKALEAL VAKGLVQALG LSNFNSRQID DILSVASVRP AVLQVECHPY LAQNELIAHC QARGLEVTAY SPLGSSDRAW RDPDEPVLLE EPVVLALAEKYGRSPAQILL RWQVQRKVIC IPKSITPSRI LQNIKVFDFT FSPEEMKQLN ALNKNWRYIV PMLTVDGKRV PRDAGHPLYP FNDPY

Tag :

Non-Tagged

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

P14550

Internal Search Terms :

Dihydrodiol dehydrogenase 3, DD3, ARM, ALR, ALDR1, aldo-keto reductase family 1 member A1 (aldehyde reductase), Aldehyde reductase, Alcohol dehydrogenase [NADP+], Alcohol dehydrogenase, AKR1A1, ATGP0433-10ug, ATGP0433-20ug, ATGP0433-50ug, ATGP0433-100ug, ATGP0433-250ug, ATGP0433-500ug, ATGP0433-1mg, ATGP0433-010, ATGP0433-020, ATGP0433-050, ATGP0433-100, ATGP0433-250, ATGP0433-500, ATGP0433-01M

more info or order :

NKMAX product webpage