protein

Recombinant human PAIP2 protein

ATGP0416

20 ug

70 USD

Recombinant human PAIP2 protein

1-127aa

ATGP0416

NP_057564

PAIP2, also known as Poly (A) -binding protein-interacting protein 2, acts as a repressor in the regulation of translation initiation of poly (A) -containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. It displaces the interaction of PABPC1 with poly (A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly (A) RNP structure organization. Recombinant PAIP2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Poly(A)-binding protein-interacting protein 2, PAIP2A, PABP- interacting protein 2, HSPC218, Poly(A)-binding protein-interacting protein 2 poly(A) binding protein interacting protein 2.

1mg/ml (determined by Bradford assay)

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Siddiqui N., et al. (2007) J Biol Chem. 282(34):25067-75. ;; Yoshida M., et al. (2006) EMBO J. 25(9):1934-44.;;

> 90% by SDS-PAGE

SDS-PAGE

Human

Metabolism

17.1 kDa (147aa) confirmed by MALDI-TOF

MKDPSRSSTS PSIINEDVII NGHSHEDDNP FAEYMWMENE EEFNRQIEEE LWEEEFIERC FQEMLEEEEE HEWFIPARDL PQTMDQIQDQ FNDLVISDGS SLEDLVVKSN LNPNAKEFVP GVKYGNI

His-Tag

E.coli

Recombinant Protein

Q9BPZ3

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