Recombinant human TC21/RRAS2 protein | NKMAX ATGP0396 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human TC21/RRAS2 protein

catalog :

ATGP0396

quantity :

20 ug

price :

55 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human TC21/RRAS2 protein

Domain :

1-201aa

Catalog number (SKU) :

ATGP0396

NCBI :

NP_036382

Description :

RAS viral (r-ras) oncogene homolog 2 isoform a, also known as RRAS2, belongs to the Ras like GTPase family that cycle between GTP-bound active and GDP-bound inactive states at the cytoplasmic face of the plasma membrane. It is implicated in the pathogenesis of human cancers. Thus, overexpression of active RRAS2 in EpH4 cells induces tumorigenicity through the phosphoinositide 3-kinase, p38 MAPK, and mTOR pathways, and these cells lose their sensitivity to the normal growth inhibitory role of TGF-beta. Recombinant human RRAS2, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

Ras-related protein R-Ras2, Related RAS viral (r-ras) oncogene homolog 2, Ras-like protein TC21, Teratocarcinoma oncogene, TC21

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 2mM EDTA

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Erdogan M., et al. (2007) J Biol Chem. 282(38):27713-20. ;; Movilla N., et al. (1999) Oncogene. 18(43):5860-9. ;;

Purity :

> 95% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Cancer

Molecular Weight :

25.2 kDa (221aa) confirmed by MALDI-TOF

Amino Acid Sequence :

MAAAGWRDGS GQEKYRLVVV GGGGVGKSAL TIQFIQSYFV TDYDPTIEDS YTKQCVIDDR AARLDILDTA GQEEFGAMRE QYMRTGEGFL LVFSVTDRGS FEEIYKFQRQ ILRVKDRDEF PMILIGNKAD LDHQRQVTQE EGQQLARQLK VTYMEASAKI RMNVDQAFHE LVRVIRKFQE QECPPSPEPT RKEKDKKGCH C

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

P62070

Internal Search Terms :

TC21, R-Ras2,ATGP0396-10ug,ATGP0396-20ug,ATGP0396-50ug,ATGP0396-100ug,ATGP0396-250ug,ATGP0396-500ug,ATGP0396-1mg,ATGP0396-10,ATGP0396-20,ATGP0396-50,ATGP0396-100,ATGP0396-250,ATGP0396-500,ATGP0396-1

more info or order :

NKMAX product webpage