protein

Recombinant human Galectin-1/LGALS1 protein

ATGP0385

20 ug

55 USD

Recombinant human Galectin-1/LGALS1 protein

1-135aa

ATGP0385

NP_002296.1

Galectin-1 is a member of the beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This protein is an autocrine negative growth factor that regulates cell proliferation. It controls cell survival by inducing apoptosis of activated T cells and immature thymocytes, thus Galectin-1 has immunosuppressive and anti-inflammatory properties. Galectin-1 also regulates tumor angiogenesis and is a target for angiostatic cancer therapy. Recombinant human Galectin-1 was expressed in E. coli and purified by using conventional chromatography

Gal-1, 14 kDa laminin-binding protein, HLBP14, 14 kDa lectin, Beta-galactoside-binding lectin L-14-I, Galaptin, HBL, HPL, Lactose-binding lectin 1, Lectin galactoside-binding soluble 1, Putative MAPK-activating protein PM12, S-Lac lectin 1, GBP

1mg/ml (determined by Bradford assay)

Liquid in. 20mM Tris-HCl buffer (pH 7.5) containing 10% glycerol

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Robert Kiss., et al. (2006). Glycobiology. 6(11):137R-157R;; Poirier F., et al. (2009). Dev Growth Differ. 51(7):607-15.;;

> 90% by SDS-PAGE

SDS-PAGE

Human

Apoptosis

14.7 kDa (135aa) confirmed by MALDI-TOF

< 1 EU per 1ug of protein (determined by LAL method)

MACGLVASNL NLKPGECLRV RGEVAPDAKS FVLNLGKDSN NLCLHFNPRF NAHGDANTIV CNSKDGGAWG TEQREAVFPF QPGSVAEVCI TFDQANLTVK LPDGYEFKFP NRLNLEAINY MAADGDFKIK CVAFD

Non-Tagged

E.coli

Recombinant Protein

P09382

Galectin1, GAL1, GBP, LGALS1, S-Lac lectin1, galaptin, lactose-binding lectin 1, 14 kDa lectin, Beta galactoside binding lectin, Beta galactoside binding lectin L 14 I, DKFZp686E23103, Galectin, Galectin1, GBP, HBL, HPL, Lactose binding lectin 1, MAPK activating protein MP12, Lectin galactoside binding soluble 1, LGALS 1, Putative MAPK activating protein MP12, S Lac lectin 1.,ATGP0385-10ug,ATGP0385-20ug,ATGP0385-50ug,ATGP0385-100ug,ATGP0385-250ug,ATGP0385-500ug,ATGP0385-1mg,ATGP0385-10,ATGP0385-20,ATGP0385-50,ATGP0385-100,ATGP0385-250,ATGP0385-500,ATGP0385-1

Suzuki O, et al. Galectin-1-mediated cell adhesion, invasion and cell death in human anaplastic large cell lymphoma: Regulatory roles of cell surface glycans. (Int J Oncol. 2014){https://pubmed.ncbi.nlm.nih.gov/24589677/};; Suzuki O, et al. Sialylation and glycosylation modulate cell adhesion and invasion to extracellular matrix in human malignant lymphoma: Dependency on integrin and the Rho GTPase family. (Int J Oncol. 2015){https://pubmed.ncbi.nlm.nih.gov/26497328/};;Campanero-Rhodes, M.A, et al. Exploration of Galectin Ligands Displayed on Gram-Negative Respiratory Bacterial Pathogens with Different Cell Surface Architectures. (Biomolecules. 2021){https://pubmed.ncbi.nlm.nih.gov/33919637/}