Recombinant human Aldo-keto Reductase 1B10/AKR1B10 protein

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human Aldo-keto Reductase 1B10/AKR1B10 protein

catalog :

ATGP0314

quantity :

20 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human Aldo-keto Reductase 1B10/AKR1B10 protein

Domain :

1-316aa

Catalog number (SKU) :

ATGP0314

NCBI :

NP_064695

Description :

AKR1B10, also known as Aldo-keto reductase family 1, member B10, AKR1B10 is a monomeric protein that efficiently catalyzes the reduction of aromatic and aliphatic aldehydes and ketones. AKR1B10 is ubiquitously expressed in many human tissues but is highly expressed in small intestine, colon and adrenal gland. This protein is pathogenically involved in diabetic complications and has been reported that AKR1B10 is overexpressed in human tumors, such as liver, breast, and lung cancer, and may play a critical role in the development and progression of cancer. Recombinant human AKR1B10 protein was expressed in E. coli and purified by using conventional chromatography.

Alternative Names :

Aldo-keto reductase family 1 member B10, AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, AKR1B10, Aldose reductase like, Aldose reductase related protein, ARL 1, hARP, SI reductase, Small intestine reductase

Concentration :

1mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Yabe D., et al. (1997) J Biol Chem. 272(29):18232-9.;; Vorum H., et al. (1998) Biochim Biophys Acta. 1386(1):121-31.;;

Purity :

> 95% by SDS-PAGE

Bioactivity Comment Only :

Specific activity is > 1,500pmol/min/ug, and was obtained by measuring the decrease of NADP in absorbance at 340nm resulting from NADPH at pH 7.0 at 37C.

Applications :

SDS-PAGE, Enzyme Activity

Antigen Species :

Human

Gene Category :

Redox Proteins

Molecular Weight :

36 kDa (316aa) confirmed by MALDI-TOF

Amino Acid Sequence :

MATFVELSTK AKMPIVGLGT WKSPLGKVKE AVKVAIDAGY RHIDCAYVYQ NEHEVGEAIQ EKIQEKAVKR EDLFIVSKLW PTFFERPLVR KAFEKTLKDL KLSYLDVYLI HWPQGFKSGD DLFPKDDKGN AIGGKATFLD AWEAMEELVD EGLVKALGVS NFSHFQIEKL LNKPGLKYKP VTNQVECHPY LTQEKLIQYC HSKGITVTAY SPLGSPDRPW AKPEDPSLLE DPKIKEIAAK HKKTAAQVLI RFHIQRNVIV IPKSVTPARI VENIQVFDFK LSDEEMATIL SFNRNWRACN VLQSSHLEDY PFDAEY

Tag :

Non-Tagged

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

O60218

Internal Search Terms :

AKR1B10, AKR1B11, AKR1B12, Aldo-keto reductase family 1, Aldo-keto reductase family 1 member B10, Aldo-keto Reductase1B10, Aldose reductase like, Aldose reductase related protein, ALDRLn, ARL 1, ARL1, ARL-1, hARP, HIS, member B10, member B10 Aldose reductase like, SI reductase, Small intestine reductase, ATGP0314-10ug, ATGP0314-20ug, ATGP0314-50ug, ATGP0314-100ug, ATGP0314-250ug, ATGP0314-500ug, ATGP0314-1mg, ATGP0314-010, ATGP0314-020, ATGP0314-050, ATGP0314-100, ATGP0314-250, ATGP0314-500, ATGP0314-01M

more info or order :

NKMAX product webpage