Recombinant human Sepiapterin reductase/SPR protein | NKMAX ATGP0288 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human Sepiapterin reductase/SPR protein

catalog :

ATGP0288

quantity :

20 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human Sepiapterin reductase/SPR protein

Domain :

1-261aa

Catalog number (SKU) :

ATGP0288

NCBI :

NP_003115

Description :

Sepiapterin reductase (SPR) belongs to the short-chain dehydrogenase/reductase (SDR) family and also reduces various exogenous carbonyl compounds including phenylpropanedione. SPR is an essential enzyme for the biosynthesis of tetrahydrobiopterin, an essential cofactor for aromatic amino acid hydrolases including tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis. Defects in SPR cause DOPA-responsive dystonia defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Recombinant human SPR protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Alternative Names :

SPR, Sepiapterin reductase, SDR38C1, Short chain dehydrogenase/reductase family 38C, member 1

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Tobin JE., et al. (2007). Brain Res. 30:42-7.;; Ohye T., et al. (1998). Biochem Biophys Res Commun. 251(2):597-602.;;

Purity :

> 95% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Redox Proteins

Molecular Weight :

30.2 kDa (281aa) confirmed by MALDI-TOF

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

MGSSHHHHHH SSGLVPRGSH MEGGLGRAVC LLTGASRGFG RTLAPLLASL LSPGSVLVLS ARNDEALRQL EAELGAERSG LRVVRVPADL GAEAGLQQLL GALRELPRPK GLQRLLLINN AGSLGDVSKG FVDLSDSTQV NNYWALNLTS MLCLTSSVLK AFPDSPGLNR TVVNISSLCA LQPFKGWALY CAGKAARDML FQVLALEEPN VRVLNYAPGP LDTDMQQLAR ETSVDPDMRK GLQELKAKGK LVDCKVSAQK LLSLLEKDEF KSGAHVDFYD K

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

P35270

Internal Search Terms :

Sepiapterin reductase, SPR, Sepiapterin reductase.,ATGP0288-10ug,ATGP0288-20ug,ATGP0288-50ug,ATGP0288-100ug,ATGP0288-250ug,ATGP0288-500ug,ATGP0288-1mg,ATGP0288-10,ATGP0288-20,ATGP0288-50,ATGP0288-100,ATGP0288-250,ATGP0288-500,ATGP0288-1

more info or order :

NKMAX product webpage