Recombinant human DTNBP1 protein | NKMAX ATGP0278 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human DTNBP1 protein

catalog :

ATGP0278

quantity :

20 ug

price :

105 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human DTNBP1 protein

Domain :

1-270aa

Catalog number (SKU) :

ATGP0278

NCBI :

NP_898862.1

Description :

Dysbindin is a ubiquitously expressed protein that binds to alpha- and beta-dystrobrevins, components of the dystrophin-associated protein complex (DPC) in both muscle and nonmuscle cells. Dysbindin has been strongly implicated in schizophrenia (SZ) susceptibility by a series of independent genetic association and gene expression studies. Among its known functions, dysbindin is part of a protein complex, termed the biogenesis of lysosome-related organelles complex 1 (BLOC-1), the molecular components of which might be involved in the regulation of vesicular trafficking and dendrite branching. Dysbindin effects for brain volume and cortical thickness appear driven by different neurobiological processes. Recombinant human Dysbindin protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Alternative Names :

Dystrobrevin-binding protein 1 isoform C, DTNBP1, DBND, HPS7, SDY, Dystrobrevin-binding protein 1 isoform C Dystrobrevin binding protein 1, Hermansky Pudlak syndrome 7 protein, Dysbindin

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 100mM NaCl, 0.5mM DTT, 20% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Li W., et al. (2003). Nat Genet. 35(1):84-9;; Chen XW., et al. (2008). J Cell Biol. 181(5):791-801;;

Purity :

> 85% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Neuroscience

Molecular Weight :

34.5 kDa (306aa) confirmed by MALDI-TOF

Amino Acid Sequence :

MLSA HWEKKKTSLV ELQEQLQQLP ALIADLESMT ANLTHLEASF EEVENNLLHL EDLCGQCELE RCKHMQSQQ LENYKKNKRKE LETFKAELDA EHAQKVLEME HTQQMKLKER QKFFEEAFQQ DMEQYLSTGY LQIAERREPI GSMSSMEVNV DMLEQMDLMD ISDQEALDVF LNSGGEENTV LSPALGPESS TCQNEITLQV PNPSELRAKP PSSSSTCTDS ATRDISEGGE SPVVQSDEEE VQVDTALATS HTDREATPDG GEDSDS

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

Q96EV8

Internal Search Terms :

Dysbindin, Dystrobrevin-binding protein 1 isoform C, DTNBP1, DBND, HPS7, SDY, Dystrobrevin-binding protein 1 isoform C Dystrobrevin binding protein 1, Hermansky Pudlak syndrome 7 protein.,ATGP0278-10ug,ATGP0278-20ug,ATGP0278-50ug,ATGP0278-100ug,ATGP0278-250ug,ATGP0278-500ug,ATGP0278-1mg,ATGP0278-10,ATGP0278-20,ATGP0278-50,ATGP0278-100,ATGP0278-250,ATGP0278-500,ATGP0278-1

more info or order :

NKMAX product webpage