Recombinant human Histamine N-Methyltransferase/HNMT protein

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human Histamine N-Methyltransferase/HNMT protein

catalog :

ATGP0273

quantity :

20 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human Histamine N-Methyltransferase/HNMT protein

Domain :

1-292aa

Catalog number (SKU) :

ATGP0273

NCBI :

AAH20677

Description :

Histamine N-methyltransferase (HNMT) is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. HNMT inactivates histamine by N-methylation. Histamine is involved in regulation and modulation of immune response through the stimulation of four distinct subtypes of receptors, H1, H2, H3, and H4, present on the target cells. Histamine is inactivated by the histamine-metabolizing enzyme histamine N-methyltransferase (HNMT) in bronchus, kidney, and the central nervous system. It plays an important role in degrading histamine and in regulating the airway response to histamine. Recombinant human HNMT protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Alternative Names :

Histamine N-methyltransferase isoform 1, Histamine N-methyltransferase isoform 1, HMT, HNMT-S1, HNMT-S2, Histamine N-methyltransferase isoform 1 EC 2.1.1.8, Histamine N methyltransferase, Hnmt, HNMT S1, HNMT S2.

Concentration :

1mg/ml (determined by Bradford assay)

Formulation :

Liquid in. 20mM Tris-HCl buffer (pH 8.0) buffer containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Garcia-Martin E., et al. (2009) Pharmacogenomics. 10(5):867-83;;Palikhe NS., et al. (2008) J Clin Pharm Ther. 33(5):465-72

Purity :

> 95% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Enzymes & Proteases

Molecular Weight :

37 kDa (328aa) confirmed by MALDI-TOF

Amino Acid Sequence :

MASS MRSLFSDHGK YVESFRRFLN HSTEHQCMQE FMDKKLPGII GRIGDTKSEI KILSIGGGAG EIDLQILSKV QAQYPGVCIN NEVVEPSAEQ IAKYKELVAK TSNLENVKFA WHKETSSEYQ SRMLEKKELQ KWDFIHMIQM LYYVKDIPAT LKFFHSLLGT NAKMLIIVVS GSSGWDKLWK KYGSRFPQDD LCQYITSDDL TQMLDNLGLK YECYDLLSTM DISDCFIDGD ENGDLLWDFL TETCNFNATA PPDLRAELGK DLQEPEFSAK KEGKVLFNNT LSFIVIEA

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

P50135

Internal Search Terms :

Histamine N-Methyltransferase, HNMT, Histamine N-methyltransferase isoform 1, Histamine N-methyltransferase isoform 1, HMT, HNMT-S1, HNMT-S2, Histamine N-methyltransferase isoform 1 EC 2.1.1.8, Histamine N methyltransferase, Hnmt, HNMT S1, HNMT S2.,ATGP0273-10ug,ATGP0273-20ug,ATGP0273-50ug,ATGP0273-100ug,ATGP0273-250ug,ATGP0273-500ug,ATGP0273-1mg,ATGP0273-10,ATGP0273-20,ATGP0273-50,ATGP0273-100,ATGP0273-250,ATGP0273-500,ATGP0273-1

more info or order :

NKMAX product webpage