product summary
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company name :
NKMAX
product type :
cDNA
product name :
SH2D1A cDNA
catalog :
ATGD0106
quantity :
10 ug
price :
99 USD
more info or order :
NKMAX product webpage
product information
Product Type :
cDNAs
Item Name :
SH2D1A cDNA
Catalog number (SKU) :
ATGD0106
NCBI :
NP_002342.1
Description :
SH2D1A encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
Alternative Names :
DSHP, EBVS, IMD5, LYP, MTCP1, SAP, SAP/SH2D1A, XLP, XLPD, XLPD1
Formulation :
Lyophilized
Storage :
Store the plasmid at -20C.
Antigen Species :
Human
Gene Category :
Immunology
Nucleotide Sequence :
ATGGACGCAGTGGCTGTGTATCATGGCAAAATCAGCAGG
GAAACCGGCGAGAAGCTCCTGCTTGCCACTGGGCTGGAT
GGCAGCTATTTGCTGAGGGACAGCGAGAGCGTGCCAGGC
GTGTACTGCCTATGTGTGCTGTATCACGGTTACATTTAT
ACATACCGAGTGTCCCAGACAGAAACAGGTTCTTGGAGT
GCTGAGACAGCACCTGGGGTACATAAAAGATATTTCCGG
AAAATAAAAAATCTCATTTCAGCATTTCAGAAGCCAGAT
CAAGGCATTGTAATACCTCTGCAGTATCCAGTTGAGAAG
AAGTCCTCAGCTAGAAGTACACAAGGTACTACAGGGATA
AGAGAAGATCCTGATGTCTGCCTGAAAGCCCCATGA
Translation Sequence :
MDAVAVYHGK ISRETGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYHGY IYTYRVSQTE TGSWSAETAP GVHKRYFRKI KNLISAFQKP DQGIVIPLQY PVEKKSSARS TQGTTGIRED PDVCLKAP
RNA Reference Number :
NM_002351.4
OMIM Number :
300490
Chromosome Location :
Xq25
DNA size :
387bp
Preparation before usage :
1. Centrifuge at 7000rpm for 1 minute.;;2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA.;;Each tube contains approximately 10ug of lyophilized plasmid.
Vector :
pATGen (puc19-derived cloning vector)
Vector description :
This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
Product Type Name :
cDNA
Internal Search Terms :
SH2D1A, DSHP, EBVS, IMD5, LYP, MTCP1, SAP, SAP/SH2D1A, XLP, XLPD, XLPD1, SH2D1A,ATGD0106-10ug,ATGD0106-20ug,ATGD0106-50ug,ATGD0106-100ug,ATGD0106-250ug,ATGD0106-500ug,ATGD0106-1mg,ATGD0106-10,ATGD0106-20,ATGD0106-50,ATGD0106-100,ATGD0106-250,ATGD0106-500,ATGD0106-1
more info or order :
NKMAX product webpage
company information
NKMAX
SNUH Health Care Innovation Park 6F
172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
https://www.nkmaxbio.com
82-31-8017-8114
headquarters: South Korea
NKMAX Co. Ltd. is a biotech company that manufactures and supplies a unique line of quality proteins and antibodies worldwide to both researchers and retailers.