Human NKp46/NCR1 antibody | NKMAX ATGA0526 product information

product summary

company name :

NKMAX

product type :

antibody

product name :

Human NKp46/NCR1 antibody

catalog :

ATGA0526

quantity :

50 ul

price :

190 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

N1d9

reactivity :

human

application :

ELISA, FACS

more info or order :

NKMAX product webpage

product information

Product Type :

Antibodies

Item Name :

Human NKp46/NCR1 antibody

Catalog number (SKU) :

ATGA0526

NCBI :

NP_004820

Description :

A natural cytotoxicity receptor (NCR), Nkp46, is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 residue stalk resion, a type I transmembrane domain, and a short cytoplasmic tail. Nkp46 has been shown to represent a novel Nk cell-specific molecule involved in human Nk cell activation. The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appearto be major triggering receptors in tumor cell recognition. Nkp46 has been implicated in Nk cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines.

Alternative Names :

NKp46 Extracellular Ig-like domain, NK-p46, NK cell-activating receptor, NCR1, NCR, Natural killer cell p46-related protein, Natural cytotoxicity triggering receptor 1 isoform a, Natural cytotoxicity triggering receptor 1, Lymphocyte antigen 94 homolog, Ly96, LY94, hNKp46, CD335 antigen

Concentration :

1mg/ml (determined by BCA assay)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Sivori, S. et al., (1997) J. Exp. Med. 186:1125-36.;;Pessino, A. et al., (1998) J. Exp. Med. 188:953-60.

Abs Host :

Mouse

Isotype :

IgG1 kappa

Immunogen :

Recombinant human Nkp46/NCR1 (22-255aa) purified from E. coli.

Applications :

ELISA, FACS

Reacts With :

Human

Clone Number :

n1D9

Ab Usage :

The antibody has been tested by ELISA and Flow cytometry to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

FACS Comment and Pic :

Flow cytometry analysis of NKp46/NCR1 in PBMC. The cell was stained with ATGA0526 at 2-5ug for 1x10^6cells (red). A Goat anti mouse IgG (Alexa fluor 488) was used as the secondary antibody. Mouse monoclonal IgG was used as the isotype control (darkgray), cells without incubation with primary and secondary antibody was used as the negative control (light gray).Flow cytometry analysis of NKp46/NCR1 in HeLa cells. The cell was stained with ATGA0526 at 2-5ug for 1x10^6cells (red). A Goat anti mouse IgG (Alexafluor 488) was used as the secondary antibody. Mouse monoclonal IgG was used as the isotype control (dark gray), cells without incubation with primary and secondary antibody was used as the negative control (light gray). {ATGA0526-FC2.jpg}

Antigen Species :

Human

Gene Category :

Immunology

Additional Comment Only :

This product was produced from tissue culture supernatant.

Conjugation :

Unconjugated

Clonality Mono VS Poly :

Monoclonal

Product Type Name :

Monoclonal Antibody

UniProt No. :

O76036

Internal Search Terms :

NKp46 Extracellular Ig-like domain, NKp-46 Extracellular Ig-like domain, NKp46, NK p46, NK-p46, NK cell-activating receptor, NCR-1, NCR 1, NCR1, NCR, Natural killer cell p46-related protein, Natural cytotoxicity triggering receptor 1 isoform a, Natural cytotoxicity triggering receptor 1, Lymphocyte antigen 94 homolog, Ly96, LY94, hNKp46, CD335 antigen, ATGA0526-10ug, ATGA0526-20ug, ATGA0526-50ug, ATGA0526-100ug, ATGA0526-250ug, ATGA0526-500ug, ATGA0526-1mg, ATGA0526-010, ATGA0526-020, ATGA0526-050, ATGA0526-100, ATGA0526-250, ATGA0526-500, ATGA0526-01M

more info or order :

NKMAX product webpage