Human Thioredoxin Reductase 1/TRXR1 antibody | NKMAX ATGA0451 product information

product summary

company name :

NKMAX

product type :

antibody

product name :

Human Thioredoxin Reductase 1/TRXR1 antibody

catalog :

ATGA0451

quantity :

50 ul

price :

170 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AT30F1

reactivity :

human

application :

western blot, ELISA, immunocytochemistry

more info or order :

NKMAX product webpage

product information

Product Type :

Antibodies

Item Name :

Human Thioredoxin Reductase 1/TRXR1 antibody

Catalog number (SKU) :

ATGA0451

NCBI :

NP_001087240

Description :

TXNRD1, also known as Thioredoxin reductase 1, is a part of a selenium-containing pyridine nucleotidedisulphide oxidoreductase family, which has a conserved catalytic site of Cys-Val-Asn-Val-Gly-Cys. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. Inhibition of TXNRD1 activity may provide for potential treatments of cancer, AIDS and other autoimmune diseases as well as bacterial infections and parasitic diseases.

Alternative Names :

GRIM 12, KDRF, KM 102 derived reductase like factor, MGC9145, Oxidoreductase, Thioredoxin reductase, Thioredoxin reductase 1, Thioredoxin reductase 1 cytoplasmic, Thioredoxin reductase 1 Gene associated with retinoid IFN induced mortality 12 protein, Thioredoxin reductase GRIM 12, TR, TR 1, TRXR 1, TXNR, TXNRD 1

Concentration :

1mg/ml (determined by BCA assay)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Ma X., et al. (2002) J Biol Chem. 277(25): 22460-8. ;; Javvadi P (2010) Cancer Res. 70(5): 1941-50.

Abs Host :

Mouse

Isotype :

IgG2b kappa

Immunogen :

Recombinant human TXNRD1 (161-647aa) purified from E. coli

Applications :

ELISA, WB, ICC/IF

IF Comment And Pic :

ICC/IF analysis of TXNRD1 in Hep3B cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human TXNRD1 antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green). {ATGA0451-IF1b.jpg}ICC/IF analysis of TXNRD1 in A549 cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human TXNRD1 antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green). {ATGA0451-IF2a.jpg} {ATGA0451-IF2b.jpg}

WB Comment and Pic :

The cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human TXNRD1 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. ;;Lane 1.: HeLa cell lysate ;;Lane 2.: A549 cell lysate ;;Lane 3.: PC3 cell lysate

Reacts With :

Human

Clone Number :

AT30F1

Ab Usage :

The antibody has been tested by ELISA, Western blot analysis, Flow cytometry and ICC/IF to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

Antigen Species :

Human

Gene Category :

Signal Transduction

Conjugation :

Unconjugated

Clonality Mono VS Poly :

Monoclonal

Ab Purification Comment :

By protein-A affinity chromatography

Product Type Name :

Monoclonal Antibody

UniProt No. :

Q16881

Internal Search Terms :

GRIM 12, GRIM12, GRIM-12, KDRF, KM 102 derived reductase like factor, MGC9145, Oxidoreductase, Thioredoxin reductase, Thioredoxin reductase 1, Thioredoxin reductase 1 cytoplasmic, Thioredoxin reductase 1 Gene associated with retinoid IFN induced mortality 12 protein, Thioredoxin reductase GRIM 12, Thioredoxin reductase GRIM12, TR, TR 1, TR1, TR-1, TRXR 1, TRXR1, TRXR-1, TXNR, TXNRD 1, TXNRD1, TXNRD-1, ATGA0451-10ug, ATGA0451-20ug, ATGA0451-50ug, ATGA0451-100ug, ATGA0451-250ug, ATGA0451-500ug, ATGA0451-1mg, ATGA0451-010, ATGA0451-020, ATGA0451-050, ATGA0451-100, ATGA0451-250, ATGA0451-500, ATGA0451-01M

more info or order :

NKMAX product webpage