Human Layilin/LAYN antibody | NKMAX ATGA0295 product information

product summary

company name :

NKMAX

product type :

antibody

product name :

Human Layilin/LAYN antibody

catalog :

ATGA0295

quantity :

50 ul

price :

170 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AT18E10

reactivity :

human

application :

western blot, ELISA

more info or order :

NKMAX product webpage

product information

Product Type :

Antibodies

Item Name :

Human Layilin/LAYN antibody

Catalog number (SKU) :

ATGA0295

NCBI :

NP_001245319

Description :

Layilin is a widely expressed integral membrane hyaluronan receptor and a transmembrane protein with homology to C-type lectins. This protein interacts with the ERM protein family of cytoskeletal membrane linker molecule members, including talin, ezrin, moesin, and radixin. The carboxy-terminal domain of layilin is capable of binding to the amino-terminal domain of radixin. An interdomain interaction between the amino- and the carboxy-terminal domains of radixin inhibits its ability to bind to layilin. Layilin plays an important role in cell adhesion and motility. It is important for the maintenance of the cortical structure in the cell because it mediates signals from the extracellular matrix to the cytoskeleton. In spreading cells, Layilin acts as a membrane-binding site for talin in the peripheral ruffles, and it may play a role in the migration of cells to a wound site.

Alternative Names :

Layilin isoform 1, Layilin

Concentration :

1mg/ml (determined by BCA assay)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Bono P., et al. (2005) Exp Cell Res 1308(1): 177-87.;; Mark L., et al. (1998) The Journal of Cell Biology 143(2): 429.;;

Abs Host :

Mouse

Isotype :

IgG1 kappa

Immunogen :

Recombinant human LAYN (22-235aa) purified from E. coli

Applications :

ELISA, WB

WB Comment and Pic :

The cell lysate(40ug) was resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human LAYN antibody (1:3000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.;; Lane 1.: A549 cell lysate

Reacts With :

Human

Clone Number :

AT18E10

Ab Usage :

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

Antigen Species :

Human

Gene Category :

Cytoskeleton

Conjugation :

Unconjugated

Clonality Mono VS Poly :

Monoclonal

Ab Purification Comment :

By protein-A affinity chromatography

Product Type Name :

Monoclonal Antibody

UniProt No. :

Q6UX15

Internal Search Terms :

Layilin, LAYN,ATGA0295-10ug,ATGA0295-20ug,ATGA0295-50ug,ATGA0295-100ug,ATGA0295-250ug,ATGA0295-500ug,ATGA0295-1mg,ATGA0295-10,ATGA0295-20,ATGA0295-50,ATGA0295-100,ATGA0295-250,ATGA0295-500,ATGA0295-1

more info or order :

NKMAX product webpage