Human PRPS1 antibody | NKMAX ATGA0279 product information

product summary

company name :

NKMAX

product type :

antibody

product name :

Human PRPS1 antibody

catalog :

ATGA0279

quantity :

50 ul

price :

170 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AT1E11

reactivity :

human

application :

western blot, ELISA, immunocytochemistry

more info or order :

NKMAX product webpage

product information

Product Type :

Antibodies

Item Name :

Human PRPS1 antibody

Catalog number (SKU) :

ATGA0279

NCBI :

NP_002755

Description :

PRPS1 is an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. A mutation in PRPS1 may result in PRPS superactivity, a disease characterized by gout and the overproduction of purine nucleotides, uric acid and PRPP. PRPS1 mutations can also lead to a reduction in PRPS1 activity resulting in ARTS syndrome or CMTX5 (Charcot-Marie-Tooth disease X-linked recessive type 5).

Alternative Names :

Ribose-phosphate pyrophosphokinase 1, ARTS, CMTX5, PPRibP, PRSI, DFN2, DFNX1, Ribose-phosphate pyrophosphokinase 1 EC 2.7.6.1, KIAA0967, Phosphoribosyl pyrophosphate synthetase I, PRS I, PRS-I, Ribose phosphate pyrophosphokinase I

Concentration :

1mg/ml (determined by BCA assay)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Ishizuka T, et al. (1992) Biochim Biophsy Acta 241130(2): 139-48.;; Kim HJ, et al. (2007) Arn J Hum Gernet 81(3):552-8.

Abs Host :

Mouse

Isotype :

IgG2a kappa

Immunogen :

Recombinant human PRPS1 (1-318aa) purified from E. coli

Applications :

ELISA, WB, ICC/IF

IF Comment And Pic :

ICC/IF analysis of PRPS1 in HeLa cells. The cell was stained with ATGA0279 (1:100). The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue).

WB Comment and Pic :

The cell lysate (40ug) was resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human PRPS1 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.;;Lane 1.: 293T cell lysate

Reacts With :

Human

Clone Number :

AT1E11

Ab Usage :

The antibody has been tested by ELISA, Western blot and ICC/IF analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

Antigen Species :

Human

Gene Category :

Epigenomics (Transcription & Translation)

Conjugation :

Unconjugated

Clonality Mono VS Poly :

Monoclonal

Ab Purification Comment :

By protein-A affinity chromatography

Product Type Name :

Monoclonal Antibody

UniProt No. :

P60891

Internal Search Terms :

PRPS1,ATGA0279-10ug,ATGA0279-20ug,ATGA0279-50ug,ATGA0279-100ug,ATGA0279-250ug,ATGA0279-500ug,ATGA0279-1mg,ATGA0279-10,ATGA0279-20,ATGA0279-50,ATGA0279-100,ATGA0279-250,ATGA0279-500,ATGA0279-1

more info or order :

NKMAX product webpage