Human CDK4 antibody | NKMAX ATGA0272 product information

product summary

company name :

NKMAX

product type :

antibody

product name :

Human CDK4 antibody

catalog :

ATGA0272

quantity :

50 ul

price :

170 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AT6D10

reactivity :

human

application :

western blot, ELISA

more info or order :

NKMAX product webpage

product information

Product Type :

Antibodies

Item Name :

Human CDK4 antibody

Catalog number (SKU) :

ATGA0272

NCBI :

NP_000066

Description :

Cyclin-dependent kinase 4, also known as CDK4, belongs to the cyclin-dependent kinases (CDK) family. CDKs are a family of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells. CDK4, in complex with D-type cyclins, is thought to regulate cell growth during the G1 phase of the cell cycle. This association with a D-type cyclin up-regulates CDK4 activity, whereas binding to the CDK inhibitor p16 down-regulates CDK4 activity.

Alternative Names :

Cyclin-dependent kinase 4, CMM3, PSK-J3

Concentration :

1mg/ml (determined by BCA assay)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Coleman KG, et al. (1997). J. Biol. Chem. 272 (30): 18869-74.;; Li J, Melvin WS, Tsai MD, Muscarella P (2004). Biochemistry 43 (14): 4394-9.;; Dai K, Kobayashi R, Beach D (1996). J. Biol. Chem. 271 (36): 22030-4.;;

Abs Host :

Mouse

Isotype :

IgG2a kappa

Immunogen :

Recombinant human CDK4 (1-303aa) purified from E. coli

Applications :

ELISA,WB

WB Comment and Pic :

The cell lysate of HeLa (40ug) was resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human CDK4 antibody (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Reacts With :

Human

Clone Number :

AT6D10

Ab Usage :

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

Antigen Species :

Human

Gene Category :

Cell Cycle

Conjugation :

Unconjugated

Clonality Mono VS Poly :

Monoclonal

Ab Purification Comment :

By protein-A affinity chromatography

Product Type Name :

Monoclonal Antibody

UniProt No. :

P11802

Internal Search Terms :

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more info or order :

NKMAX product webpage