Human HAX-1 antibody | NKMAX ATGA0156 product information

product summary

company name :

NKMAX

product type :

antibody

product name :

Human HAX-1 antibody

catalog :

ATGA0156

quantity :

50 ul

price :

170 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AT3C5

reactivity :

human

application :

western blot, ELISA, immunocytochemistry

more info or order :

NKMAX product webpage

product information

Product Type :

Antibodies

Item Name :

Human HAX-1 antibody

Catalog number (SKU) :

ATGA0156

NCBI :

NP_006109

Description :

HAX1 is known to associate with hematopoietic cell-specific Lyn substrate 1 (HS1), one of the substrates of receptor-coupled tyrosine kinases activated during clonal expansion and deletion in lymphoid cells. It also interacts with the product of the polycystic kidney disease 2 (PKD2) gene and with the F-actin-binding protein, cortactin. HAX1 is also reported to bind to hairpin structures in vimentin and DNA polymerase beta mRNAs, so may play a role in mRNA stability and transport. It may also function in promoting cell survival. Defects in HAX1 are the cause of autosomal recessive severe congenital neutropenia 3 (SCN3) also called Kostmann disease.

Alternative Names :

HCLS1 associated protein X-1, HS1BP1, HCLSBP1, HCLS1 (and PKD2) associated protein

Concentration :

1mg/ml (determined by BCA assay)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Klein C, et al., (2007) Nat Genet. 39(1):86-92.;; Yin H, et al., (2001) Cytokine. 15(3):122-37.

Abs Host :

Mouse

Isotype :

IgG2b kappa

Immunogen :

Recombinant human HAX1 (1-279aa) purified from E. coli

Applications :

ELISA,WB,ICC/IF

IF Comment And Pic :

ICC/IF analysis of HAX-1 in HeLa cells. The cell was stained with ATGA0156 (1:100). The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue).

WB Comment and Pic :

The cell lysate of HeLa(30ug) was resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human HAX-1 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.;;The cell lysate(40ug) was resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human HAX-1 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.;;Lane 1.: Raji cell lysate;;{ATGA0156-WB2.jpg}

Reacts With :

Human

Clone Number :

AT3C5

Ab Usage :

The antibody has been tested by ELISA, Western blot and ICC/IF analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

Antigen Species :

Human

Gene Category :

Metabolism

Conjugation :

Unconjugated

Clonality Mono VS Poly :

Monoclonal

Ab Purification Comment :

By protein-G affinity chromatography

Product Type Name :

Monoclonal Antibody

UniProt No. :

O00165

Internal Search Terms :

HAX1,ATGA0156-10ug,ATGA0156-20ug,ATGA0156-50ug,ATGA0156-100ug,ATGA0156-250ug,ATGA0156-500ug,ATGA0156-1mg,ATGA0156-10,ATGA0156-20,ATGA0156-50,ATGA0156-100,ATGA0156-250,ATGA0156-500,ATGA0156-1

more info or order :

NKMAX product webpage