Human EPM2A antibody | NKMAX AEP0911 product information

product summary

company name :

NKMAX

product type :

antibody

product name :

Human EPM2A antibody

catalog :

AEP0911

quantity :

50 ul

price :

170 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

k2A3

reactivity :

human

application :

western blot, ELISA, immunocytochemistry

more info or order :

NKMAX product webpage

product information

Product Type :

Antibodies

Item Name :

Human EPM2A antibody

Catalog number (SKU) :

AEP0911

NCBI :

NP_005661

Description :

Epilepsy, progressive myoclonus type 2A (EPM2A), also known as laforin, is a dual-specificity phosphatase that associates with polyribosomes. The protein may be involved in the control of glycogen metabolism, particularly in monitoring for and preventing the formation of poorly branched glycogen molecules. Defects in EPM2A are a cause of progressive myoclonic epilepsy type 2 (EPM2), also known as Lafora disease. EPM2 is an autosomal recessive and severe form of adolescent-onset progressive epilepsy.

Alternative Names :

Laforin isoform a,epilepsy, progressive myoclonus type 2A Lafora disease (laforin), epilepsy progressive myoclonus type 2 Lafora disease (laforin), LDE, LD

Concentration :

1mg/ml (determined by BCA assay)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Tagliabracci V.S., et al. (2007) Proc Natl Acad Sci U S A. 104(49):19262-19266.;; Wang W., et al. (2006) Biochem Biophys Res Cimmun. 350(3):588-592.;; Ganesh S., et al. (2002) Hum Mol Genet. 11:1263-1271.

Abs Host :

Mouse

Isotype :

IgG1 kappa

Immunogen :

Recombinant human EPM2A (243-331aa) purified from E. coli

Applications :

ELISA,WB,ICC/IF

IF Comment And Pic :

ICC/IF analysis of EPM2A in HeLa cells. The cell was stained with AEP0911 (1:100). The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue).

WB Comment and Pic :

The cell lysates of HeLa and 293T (20ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human EPM2A (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Reacts With :

Human

Clone Number :

k2A3

Ab Usage :

The antibody has been tested by ELISA, Western blot and ICC/IF analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

Antigen Species :

Human

Gene Category :

Enzymes & Proteases

Conjugation :

Unconjugated

Clonality Mono VS Poly :

Monoclonal

Ab Purification Comment :

By protein-G affinity chromatography

Product Type Name :

Monoclonal Antibody

UniProt No. :

O95278

Internal Search Terms :

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more info or order :

NKMAX product webpage