protein

Recombinant human PD-L1/B7-H1 protein (CD274)

ATGP1543

10 ug

50 USD

Recombinant human PD-L1/B7-H1 protein (CD274)

19-238aa

ATGP1543

NP_054862

CD274, also known as programmed cell death 1 ligand 1 (PDCD1L1), is involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. This protein interaction with PDCD1 inhibits T-cell proliferation and cytokine production. Recombinant human CD274 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Programmed cell death 1 ligand, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1

1mg/ml (determined by Bradford assay)

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Dong H., et al. (1999) Nat. Med. 5:1365-1369;; Freeman G.J., et al. (2000) J. Exp. Med. 192:1027-1034

> 90% by SDS-PAGE

SDS-PAGE

Human

Immunology

27.9 kDa (245aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

FTVTV PKDLYVVEYG SNMTIECKFP VEKQLDLAAL IVYWEMEDKN IIQFVHGEED LKVQHSSYRQ RARLLKDQLS LGNAALQITD VKLQDAGVYR CMISYGGADY KRITVKVNAP YNKINQRILV VDPVTSEHEL TCQAEGYPKA EVIWTSSDHQ VLSGKTTTTN SKREEKLFNV TSTLRINTTT NEIFYCTFRR LDPEENHTAE LVIPELPLAH PPNER

His-Tag

E.coli

Recombinant Protein

Q9NZQ7

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