Recombinant Human Glutathione peroxidase 1 (GPX1) | MyBioSource MBS968550 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Glutathione peroxidase 1 (GPX1)

catalog :

MBS968550

quantity :

0.5 mg (E-Coli)

price :

950 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS968550

products type :

Recombinant Protein

products full name :

Recombinant Human Glutathione peroxidase 1 (GPX1)

products short name :

Glutathione peroxidase 1 (GPX1)

products name syn :

Glutathione peroxidase 1; GPx-1; GSHPx-1; EC=1.11.1.9; Cellular glutathione peroxidase

other names :

glutathione peroxidase 1 isoform 1; Glutathione peroxidase 1; glutathione peroxidase 1; GPx-1; GSHPx-1; cellular glutathione peroxidase; glutathione peroxidase 1; Cellular glutathione peroxidase

products gene name :

GPX1

other gene names :

GPX1; GPX1; GPXD; GSHPX1; GPx-1; GSHPx-1

uniprot entry name :

GPX1_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

1-203

sequence length :

203

sequence :

MCAARLAAAA AAAQSVYAFS ARPLAGGEPV SLGSLRGKVL LIENVASLUG TTVRDYTQMN ELQRRLGPRG LVVLGFPCNQ FGHQENAKNE EILNSLKYVR PGGGFEPNFM LFEKCEVNGA GAHPLFAFLR EALPAPSDDA TALMTDPKLI TWSPVCRNDV AWNFEKFLVG PDGVPLRRYS RRFQTIDIEP DIEALLSQGP SCA

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Homo sapiens (Human)

products description :

Protects the hemoglobin in erythrocytes from oxidative breakdown.

ncbi gi num :

41406084

ncbi acc num :

NP_000572.2

ncbi gb acc num :

NM_000581.2

uniprot acc num :

P07203

ncbi mol weight :

10,289 Da

ncbi pathways :

Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Arachidonic Acid Metabolism Pathway (82991); Arachidonic Acid Metabolism Pathway (685553); Arachidonic Acid Metabolism Pathway (366); Direct P53 Effectors Pathway (137939); Folate Metabolism Pathway (198833); Glutathione Metabolism Pathway (82973); Glutathione Metabolism Pathway (198824); Glutathione Metabolism Pathway (343)

ncbi summary :

This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

GPX1: Protects the hemoglobin in erythrocytes from oxidative breakdown. Homotetramer. Interacts with MIEN1. Belongs to the glutathione peroxidase family. Protein type: Oxidoreductase; Other Amino Acids Metabolism - glutathione; Lipid Metabolism - arachidonic acid; EC 1.11.1.9. Chromosomal Location of Human Ortholog: 3p21.3. Cellular Component: mitochondrion; mitochondrial matrix; cytoplasm; nucleus; cytosol. Molecular Function: selenium binding; glutathione binding; phospholipid-hydroperoxide glutathione peroxidase activity; glutathione peroxidase activity; SH3 domain binding. Biological Process: response to nicotine; fat cell differentiation; blood vessel endothelial cell migration; myoblast proliferation; response to toxin; skeletal muscle fiber development; negative regulation of caspase activity; thermoregulation; regulation of gene expression, epigenetic; vasodilation; response to estradiol stimulus; endothelial cell development; regulation of mammary gland epithelial cell proliferation; response to selenium ion; sensory perception of sound; glutathione metabolic process; lipoxygenase pathway; UV protection; response to symbiotic bacterium; hydrogen peroxide catabolic process; response to folic acid; regulation of neuron apoptosis; response to glucose stimulus; response to gamma radiation; arachidonic acid metabolic process; negative regulation of inflammatory response to antigenic stimulus; aging; protein amino acid oxidation; nucleobase, nucleoside and nucleotide metabolic process; skeletal muscle regeneration; angiogenesis involved in wound healing; purine base metabolic process; positive regulation of protein kinase B signaling cascade; response to xenobiotic stimulus; response to reactive oxygen species; triacylglycerol metabolic process; response to hydrogen peroxide; heart contraction; response to lipid hydroperoxide; cell redox homeostasis; purine nucleotide catabolic process; interaction with symbiont; induction of apoptosis by oxidative stress. Disease: Glutathione Peroxidase Deficiency

size1 :

0.5 mg (E-Coli)

price1 :

950 USD

size2 :

0.05 mg (Baculovirus)

price2 :

950

size3 :

0.5 mg (Yeast)

price3 :

1175

size4 :

0.05 mg (Mammalian-Cell)

price4 :

1175

size5 :

1 mg (E-Coli)

price5 :

1425

more info or order :

MyBioSource product webpage