protein

Recombinant Human Signal transducer and activator of transcription 5B (STAT5B)

MBS968437

1 mg (E-Coli)

1375 USD

Recombinant Protein

Recombinant Human Signal transducer and activator of transcription 5B (STAT5B)

Signal transducer and activator of transcription 5B (STAT5B)

Recombinant Signal transducer and activator of transcription 5B (STAT5B); Signal transducer and activator of transcription 5B

signal transducer and activator of transcription 5B; Signal transducer and activator of transcription 5B; signal transducer and activator of transcription 5B; transcription factor STAT5B; signal transducer and activator of transcription 5B

STAT5B

STAT5B; STAT5B; STAT5

STA5B_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

1-787

787

MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIE
SQAWDSVDLDNPQENIKATQLLEGLVQELQKKAEHQVGE
DGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQ
RLVREANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQ
DTENELKKLQQTQEYFIIQYQESLRIQAQFGPLAQLSPQ
ERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQ
KTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLD
VLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEM
LAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAAT
VRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRN
DYSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRSDR
RGAESVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVV
IVHGSQDNNATATVLWDNAFAEPGRVPFAVPDKVLWPQL
CEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLE
DYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHL
KPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEI
GGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRLGDL
NYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKP
QIKQVVPEFVNASADAGGGSATYMDQAPSPAVCPQAHYN
MYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQ
WIPHAQS

>90%(SDS-PAGE)

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Species: Homo sapiens (Human)

Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription.

21618344

NP_036580.2

NM_012448.3

P51692

88kD

Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Adipogenesis Pathway (198832); Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); CXCR4-mediated Signaling Events Pathway (137910); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Chronic Myeloid Leukemia Pathway (83116); Chronic Myeloid Leukemia Pathway (528); Cytokine Signaling In Immune System Pathway (366171)

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]

STAT5B: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases triggered by cytokines including IL2, IL3, GM-CSF, and various growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Protein type: Oncoprotein; DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 17q11.2. Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus. Molecular Function: protein dimerization activity; protein binding; signal transducer activity; double-stranded DNA binding; chromatin binding; transcription factor activity; protein phosphatase binding; glucocorticoid receptor binding. Biological Process: positive regulation of interleukin-2 biosynthetic process; T cell differentiation in the thymus; response to lipopolysaccharide; positive regulation of multicellular organism growth; female pregnancy; 2-oxoglutarate metabolic process; sequestering of lipid; allantoin metabolic process; natural killer cell differentiation; regulation of steroid metabolic process; acute-phase response; T cell homeostasis; Peyer s patch development; isoleucine metabolic process; positive regulation of natural killer cell proliferation; valine metabolic process; development of secondary female sexual characteristics; JAK-STAT cascade; regulation of transcription from RNA polymerase II promoter; response to ethanol; regulation of epithelial cell differentiation; positive regulation of transcription from RNA polymerase II promoter; taurine metabolic process; negative regulation of apoptosis; lactation; transcription from RNA polymerase II promoter; succinate metabolic process; oxaloacetate metabolic process; positive regulation of smooth muscle cell proliferation; progesterone metabolic process; positive regulation of mitotic cell cycle; fatty acid metabolic process; positive regulation of activated T cell proliferation; response to estradiol stimulus; positive regulation of natural killer cell differentiation; luteinization; development of secondary male sexual characteristics; creatinine metabolic process; positive regulation of gamma-delta T cell differentiation; negative regulation of erythrocyte differentiation; citrate metabolic process; regulation of multicellular organism growth; positive regulation of cell motility; positive regulation of natural killer cell mediated cytotoxicity; liver development; creatine metabolic process; cellular response to hormone stimulus; response to hypoxia; positive regulation of B cell differentiation; positive regulation of inflammatory response. Disease: Growth Hormone Insensitivity With Immunodeficiency

1 mg (E-Coli)

1375 USD

1 mg (Yeast)

1835