Recombinant Human Bone morphogenetic protein 1 | MyBioSource MBS968295 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Bone morphogenetic protein 1

catalog :

MBS968295

quantity :

0.05 mg (E-Coli)

price :

185 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS968295

products type :

Recombinant Protein

products full name :

Recombinant Human Bone morphogenetic protein 1

products short name :

Bone morphogenetic protein 1

products name syn :

Mammalian tolloid protein; mTld; Procollagen C-proteinase; PCP

other names :

bone morphogenetic protein 1 isoform 1; Bone morphogenetic protein 1; bone morphogenetic protein 1; bone morphogenetic protein 1; Mammalian tolloid protein; mTld; Procollagen C-proteinase; PCP

products gene name :

BMP1

products gene name syn :

PCOLC

other gene names :

BMP1; BMP1; PCP; TLD; OI13; PCP2; PCOLC; PCOLC; BMP-1; mTld; PCP

uniprot entry name :

BMP1_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

121-986

sequence length :

730

sequence :

AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWE
KHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQA
ISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIV
RENIQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNT
FSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQARK
LYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISV
TPGEKIILNFTSLDLYRSRLC

purity :

Greater than 90% as determined by SDS-PAGE.

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

products categories :

Developmental Biology

products description :

Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX.

products references :

The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1.Li S.W., Sieron A.L., Fertala A., Hojima Y., Arnold W.V., Prockop D.J.Proc. Natl. Acad. Sci. U.S.A. 93:5127-5130(1996) Novel regulators of bone formation molecular clones and activities.Wozney J.M., Rosen V., Celeste A.J., Mitsock L.M., Whitters M.J., Kriz R.W., Hewick R.M., Wang E.A.Science 242:1528-1534(1988) Three alternatively spliced variants of the gene coding for the human bone morphogenetic protein-1.Janitz M., Heiser V., Boettcher U., Landt O., Lauster R.J. Mol. Med. 76:141-146(1998) Bone morphogenetic protein-1 and a mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues.Takahara K., Lyons G.E., Greenspan D.S.J. Biol. Chem. 269:32572-32578(1994)

ncbi gi num :

4502421

ncbi acc num :

NP_001190.1

ncbi gb acc num :

NM_001199.3

uniprot acc num :

P13497

ncbi mol weight :

102.1kD

ncbi pathways :

Adipogenesis Pathway (198832); Anchoring Fibril Formation Pathway (1270248); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (1270247); Cardiac Progenitor Differentiation Pathway (712094); Collagen Biosynthesis And Modifying Enzymes Pathway (1270246); Collagen Formation Pathway (1270245); Crosslinking Of Collagen Fibrils Pathway (1270249); Degradation Of The Extracellular Matrix Pathway (1270257); Extracellular Matrix Organization Pathway (1270244); HDL-mediated Lipid Transport Pathway (1270007)

ncbi summary :

This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq, Aug 2008]

uniprot summary :

BMP1: Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Defects in BMP1 are a cause of autosomal recessive osteogenesis imperfecta (AR-OI). A connective tissue disorder characterized by bone fragility, progressively deforming bones, bowing of limbs due to multiple fractures, very short stature, a triangular face, severe scoliosis, and grayish sclera. AR-OI due to BMP1 mutations belongs to the group of osteogenesis imperfecta type III in the Sillence classification. Belongs to the peptidase M12A family. 7 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.4.24.19; Protease; Cytokine. Chromosomal Location of Human Ortholog: 8p21.3. Cellular Component: extracellular region; extracellular space; Golgi apparatus; proteinaceous extracellular matrix. Molecular Function: calcium ion binding; cytokine activity; growth factor activity; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein binding; transforming growth factor beta receptor binding; zinc ion binding. Biological Process: BMP signaling pathway; cartilage condensation; cell development; extracellular matrix disassembly; extracellular matrix organization and biogenesis; lipoprotein metabolic process; multicellular organismal development; ossification; proteolysis; regulation of apoptosis; regulation of MAPKKK cascade; skeletal development. Disease: Osteogenesis Imperfecta, Type Xiii

size1 :

0.05 mg (E-Coli)

price1 :

185 USD

size2 :

0.2 mg (E-Coli)

price2 :

420

size3 :

0.5 mg (E-Coli)

price3 :

680

size4 :

1 mg (E-Coli)

price4 :

1070

more info or order :

MyBioSource product webpage