protein

Recombinant Human Signal transducer CD24 (CD24)

MBS967923

1 mg (E-Coli)

1375 USD

Recombinant Protein

Recombinant Human Signal transducer CD24 (CD24)

Signal transducer CD24 (CD24)

signal transducer CD24; Signal transducer CD24; signal transducer CD24; CD24 antigen (small cell lung carcinoma cluster 4 antigen); CD24 molecule; Small cell lung carcinoma cluster 4 antigen

Recombinant Signal transducer CD24 (CD24); Signal transducer CD24; Small cell lung carcinoma cluster 4 antigen CD_antigen= CD24

CD24; CD24; CD24A; CD24A

CD24_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

>90%

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Species: Homo sapiens (Human)

CD24; CD24A

7019343

NP_037362.1

NM_013230.2

P25063

8,097 Da

Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489)

This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and in many B cells. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. [provided by RefSeq, Jul 2008]

CD24: Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. Genetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS). A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Polymorphisms in CD24 may act as a genetic modifier for susceptibility and progression of MS in some populations, perhaps by affecting the efficiency of CD24 expression on the cell surface. Belongs to the CD24 family. Protein type: Cell development/differentiation; Membrane protein, GPI anchor; Cell surface; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 6q21. Cellular Component: cell surface; membrane; plasma membrane; lipid raft. Molecular Function: protein binding; signal transducer activity; protein tyrosine kinase activator activity; protein kinase binding. Biological Process: respiratory burst; axon guidance; cell migration; Wnt receptor signaling pathway; regulation of phosphorylation; B cell receptor transport into lipid raft; immune response-regulating cell surface receptor signaling pathway; chemokine receptor transport out of lipid raft; positive regulation of activated T cell proliferation; cell activation; positive regulation of MAP kinase activity; cell-cell adhesion; elevation of cytosolic calcium ion concentration; cholesterol homeostasis; response to estrogen stimulus; response to molecule of bacterial origin; regulation of MAPKKK cascade; T cell costimulation; regulation of epithelial cell differentiation; negative regulation of transforming growth factor-beta3 production; response to hypoxia; regulation of cytokine and chemokine mediated signaling pathway. Disease: Multiple Sclerosis, Susceptibility To

1 mg (E-Coli)

1375 USD

1 mg (Yeast)

1835