product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Mouse Protein atonal homolog 1 (Atoh1)
catalog :
MBS967641
quantity :
0.5 mg (E-Coli)
price :
1115 USD
more info or order :
product information
catalog number :
MBS967641
products type :
Recombinant Protein
products full name :
Recombinant Mouse Protein atonal homolog 1 (Atoh1)
products short name :
Protein atonal homolog 1 (Atoh1)
products name syn :
Protein atonal homolog 1; Helix-loop-helix protein mATH-1; mATH1
other names :
protein atonal homolog 1; Protein atonal homolog 1; protein atonal homolog 1; helix-loop-helix protein mATH-1; atonal homolog 1 (Drosophila); Helix-loop-helix protein mATH-1; mATH1
products gene name :
Atoh1
products gene name syn :
Atoh1; Ath1
other gene names :
Atoh1; Atoh1; Hath1; Math1; MATH-1; bHLHa14; Ath1; mATH1
uniprot entry name :
ATOH1_MOUSE
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
1-351
sequence length :
351
sequence :
MSRLLHAEEW AEVKELGDHH RHPQPHHVPP LTPQPPATLQ ARDLPVYPAE LSLLDSTDPR AWLTPTLQGL CTARAAQYLL HSPELGASEA AAPRDEADSQ GELVRRSGCG GLSKSPGPVK VREQLCKLKG GVVVDELGCS RQRAPSSKQV NGVQKQRRLA ANARERRRMH GLNHAFDQLR NVIPSFNNDK KLSKYETLQM AQIYINALSE LLQTPNVGEQ PPPPTASCKN DHHHLRTASS YEGGAGASAV AGAQPAPGGG PRPTPPGPCR TRFSGPASSG GYSVQLDALH FPAFEDRALT AMMAQKDLSP SLPGGILQPV QEDNSKTSPR SHRSDGEFSP HSHYSDSDEA S
purity :
>90%
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
other info1 :
Species: Mus musculus (Mouse)
products description :
Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.
ncbi gi num :
6680742
ncbi acc num :
NP_031526.1
ncbi gb acc num :
NM_007500.4
uniprot acc num :
P48985
ncbi mol weight :
40kD
uniprot summary :
ATOH1: a conserved transcription factor that regulates secretory cell differentiation in colonic epithelium. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. May play a role in the differentiation of subsets of neural cells by activating E box- dependent transcription . Efficient DNA binding requires dimerization with another bHLH protein. Loss of ATOH1 expression in the colon of mice initiates colon cancer. ATOH1 has been silenced in most human colon cancers, and reactivation of this gene in cultured human colon cancer cells is anti-proliferative and induces apoptosis. Protein type: DNA-binding; Cell development/differentiation; Transcription factor. Cellular Component: nucleus. Molecular Function: protein dimerization activity; protein binding; DNA binding; chromatin DNA binding; sequence-specific DNA binding. Biological Process: transcription from RNA polymerase II promoter; axon guidance; nervous system development; inner ear morphogenesis; auditory receptor cell fate determination; transcription, DNA-dependent; regulation of neuron differentiation; multicellular organismal development; neuron migration; auditory receptor cell differentiation; neuron differentiation; regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; brain development; positive regulation of auditory receptor cell differentiation; auditory receptor cell fate specification; cerebral cortex development; positive regulation of neuron differentiation; cell differentiation; inner ear development; negative regulation of apoptosis
size1 :
0.5 mg (E-Coli)
price1 :
1115 USD
size2 :
0.05 mg (Baculovirus)
price2 :
1115
size3 :
0.5 mg (Yeast)
price3 :
1345
size4 :
0.05 mg (Mammalian-Cell)
price4 :
1345
size5 :
1 mg (E-Coli)
price5 :
1765
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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