catalog number :
MBS967255
products type :
Recombinant Protein
products full name :
Recombinant Human NADPH--cytochrome P450 reductase (POR)
products short name :
NADPH--cytochrome P450 reductase (POR)
other names :
NADPH--cytochrome P450 reductase; NADPH--cytochrome P450 reductase; NADPH--cytochrome P450 reductase; NADPH-dependent cytochrome P450 reductase; P450 (cytochrome) oxidoreductase
other gene names :
POR; POR; CPR; CYPOR; P450R; CYPOR; CPR; P450R
uniprot entry name :
NCPR_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
2-677
sequence :
GDSHVDTSS TVSEAVAEEV SLFSMTDMIL FSLIVGLLTY WFLFRKKKEE VPEFTKIQTL TSSVRESSFV EKMKKTGRNI IVFYGSQTGT AEEFANRLSK DAHRYGMRGM SADPEEYDLA DLSSLPEIDN ALVVFCMATY GEGDPTDNAQ DFYDWLQETD VDLSGVKFAV FGLGNKTYEH FNAMGKYVDK RLEQLGAQRI FELGLGDDDG NLEEDFITWR EQFWPAVCEH FGVEATGEES SIRQYELVVH TDIDAAKVYM GEMGRLKSYE NQKPPFDAKN PFLAAVTTNR KLNQGTERHL MHLELDISDS KIRYESGDHV AVYPANDSAL VNQLGKILGA DLDVVMSLNN LDEESNKKHP FPCPTSYRTA LTYYLDITNP PRTNVLYELA QYASEPSEQE LLRKMASSSG EGKELYLSWV VEARRHILAI LQDCPSLRPP IDHLCELLPR LQARYYSIAS SSKVHPNSVH ICAVVVEYET KAGRINKGVA TNWLRAKEPA GENGGRALVP MFVRKSQFRL PFKATTPVIM VGPGTGVAPF IGFIQERAWL RQQGKEVGET LLYYGCRRSD EDYLYREELA QFHRDGALTQ LNVAFSREQS HKVYVQHLLK QDREHLWKLI EGGAHIYVCG DARNMARDVQ NTFYDIVAEL GAMEHAQAVD YIKKLMTKGR YSLDVWS
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
other info1 :
Tag Information: His tagged (Host tag may vary. Please inquire for specific tag information). Species: Homo sapiens (Human)
other info2 :
Storage Buffer: Tris-based buffer,50% glycerol. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
products description :
POR; CYPOR
ncbi acc num :
NP_000932.3
ncbi gb acc num :
NM_000941.2
ncbi mol weight :
76,690 Da
ncbi pathways :
1,25-dihydroxyvitamin D3 Biosynthesis Pathway 545291!!1,25-dihydroxyvitamin D3 Biosynthesis Pathway 138457!!Bile Acid Biosynthesis, Neutral Pathway 545316!!Bile Acid Biosynthesis, Neutral Pathway 138622!!Cytochrome P450 Pathway 198773!!Melatonin Degradation I Pathway 545356!!Melatonin Degradation I Pathway 545637!!Superpathway Of Melatonin Degradation 545640!!Superpathway Of Melatonin Degradation 545359!!Tryptophan Utilization I Pathway 835392
ncbi summary :
This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq, Jul 2008]
size :
1 mg (E Coli Derived)