Recombinant Human Ephrin type-A receptor 4 (EPHA4) | MyBioSource MBS967197 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Ephrin type-A receptor 4 (EPHA4)

catalog :

MBS967197

quantity :

0.5 mg (E-Coli)

price :

1320 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS967197

products type :

Recombinant Protein

products full name :

Recombinant Human Ephrin type-A receptor 4 (EPHA4)

products short name :

Ephrin type-A receptor 4 (EPHA4)

products name syn :

Ephrin type-A receptor 4; EC=2.7.10.1; EPH-like kinase 8; EK8; hEK8; Tyrosine-protein kinase TYRO1; Tyrosine-protein kinase receptor SEK

other names :

ephrin type-A receptor 4; Ephrin type-A receptor 4; ephrin type-A receptor 4; EK8; EPH-like kinase 8; TYRO1 protein tyrosine kinase; tyrosine-protein kinase TYRO1; tyrosine-protein kinase receptor SEK; receptor protein-tyrosine kinase HEK8; EPH receptor A4; EPH-like kinase 8; EK8; hEK8; Tyrosine-protein kinase TYRO1; Tyrosine-protein kinase receptor SEK

products gene name :

EPHA4

products gene name syn :

EPHA4; HEK8; SEK; TYRO1

other gene names :

EPHA4; EPHA4; SEK; HEK8; TYRO1; HEK8; SEK; TYRO1; EK8; hEK8

uniprot entry name :

EPHA4_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

20-547

sequence length :

528

sequence :

V TGSRVYPANE VTLLDSRSVQ GELGWIASPL EGGWEEVSIM DEKNTPIRTY QVCNVMEPSQ NNWLRTDWIT REGAQRVYIE IKFTLRDCNS LPGVMGTCKE TFNLYYYESD NDKERFIREN QFVKIDTIAA DESFTQVDIG DRIMKLNTEI RDVGPLSKKG FYLAFQDVGA CIALVSVRVF YKKCPLTVRN LAQFPDTITG ADTSSLVEVR GSCVNNSEEK DVPKMYCGAD GEWLVPIGNC LCNAGHEERS GECQACKIGY YKALSTDATC AKCPPHSYSV WEGATSCTCD RGFFRADNDA ASMPCTRPPS APLNLISNVN ETSVNLEWSS PQNTGGRQDI SYNVVCKKCG AGDPSKCRPC GSGVHYTPQQ NGLKTTKVSI TDLLAHTNYT FEIWAVNGVS KYNPNPDQSV SVTVTTNQAA PSSIALVQAK EVTRYSVALA WLEPDRPNGV ILEYEVKYYE KDQNERSYRI VRTAARNTDI KGLNPLTSYV FHVRARTAAG YGDFSEPLEV TTNTVPSRII GDGANST

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Homo sapiens (Human)

ncbi gi num :

4758280

ncbi acc num :

NP_004429.1

ncbi gb acc num :

NM_004438.3

uniprot acc num :

P54764

ncbi mol weight :

104,507 Da

ncbi pathways :

Axon Guidance Pathway (83065); Axon Guidance Pathway (476); EPHA Forward Signaling Pathway (138041); EphrinA-EPHA Pathway (137942); Spinal Cord Injury Pathway (739007)

ncbi summary :

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]

uniprot summary :

EphA4: a tyrosine kinase receptor of the Eph family. Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in hindbrain pattern formation. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. Protein type: Protein kinase, TK; Kinase, protein; Membrane protein, integral; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; Eph family. Chromosomal Location of Human Ortholog: 2q36.1. Cellular Component: Golgi apparatus; cell surface; endoplasmic reticulum; integral to plasma membrane; dendrite; postsynaptic density; dendritic spine; perikaryon; postsynaptic membrane; mitochondrial outer membrane; early endosome membrane; axon; cytoplasm; plasma membrane; nerve terminal; cell junction; neuromuscular junction; filopodium. Molecular Function: identical protein binding; protein binding; ephrin receptor binding; transmembrane-ephrin receptor activity; GPI-linked ephrin receptor activity; PH domain binding; ATP binding; protein kinase activity. Biological Process: axon guidance; positive regulation of JNK activity; peptidyl-tyrosine phosphorylation; negative regulation of axon regeneration; protein amino acid autophosphorylation; motor axon guidance; regulation of astrocyte differentiation; positive regulation of dendrite morphogenesis; glial cell migration; regulation of axonogenesis; adult walking behavior; ephrin receptor signaling pathway; cell adhesion; corticospinal tract morphogenesis

size1 :

0.5 mg (E-Coli)

price1 :

1320 USD

size2 :

0.05 mg (Baculovirus)

price2 :

1320

size3 :

0.5 mg (Yeast)

price3 :

1540

size4 :

0.05 mg (Mammalian-Cell)

price4 :

1540

size5 :

1 mg (E-Coli)

price5 :

2180

more info or order :

MyBioSource product webpage