catalog number :
MBS967064
products type :
Recombinant Protein
products full name :
Recombinant Rat Glutaminase kidney isoform, mitochondrial (Gls)
products short name :
Glutaminase kidney isoform, mitochondrial (Gls)
products name syn :
Glutaminase kidney isoform, mitochondrial; GLS; EC=3.5.1.2; K-glutaminase; L-glutamine amidohydrolaseCleaved into the following 2 chains:; 1. Glutaminase kidney isoform 68 kDa chain; 2. Glutaminase kidney isoform 65 kDa chain
other names :
glutaminase kidney isoform, mitochondrial isoform b; Glutaminase kidney isoform, mitochondrial; glutaminase kidney isoform, mitochondrial; K-glutaminase; L-glutamine amidohydrolase; glutaminase; K-glutaminase; L-glutamine amidohydrolaseCleaved into the following 2 chains:Glutaminase kidney isoform 68 kDa chain; Glutaminase kidney isoform 65 kDa chain
other gene names :
Gls; Gls; Glut; RATGLUT; GLS
uniprot entry name :
GLSK_RAT
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
17-674
sequence :
PPAA VGGVLRRTQP LGTLCRRPRG GSRPAAGLVA AARLHPWWGG GGRAKGPGSG GLSSSPSEIL QELGKGGTPP QQQQQQQQQP GASPPAAPGP KDSPGETDAF GNSEGKEMVA AGDNKVKQGL LPSLEDLLFY TIAEGQEKIP VHKFITALKS TGLRTSDPRL KECMDMLRLT LQTTSDGVML DKDLFKKCVQ SNIVLLTQAF RRKFVIPDFM SFTSHIDELY ESAKKQSGGK VADYIPQLAK FSPDLWGVSV CTVDGQRHSI GDTKVPFCLQ SCVKPLKYAI AVNDLGTEYV HRYVGKEPSG LRFNKLFLNE DDKPHNPMVN AGAIVVTSLI KQGVNNAEKF DYVMQFLNKM AGNEYVGFSN ATFQSERESG DRNFAIGYYL KEKKCFPEGT DMVGILDFYF QLCSIEVTCE SASVMAATLA NGGFCPITGE RVLSPEAVRN TLSLMHSCGM YDFSGQFAFH VGLPAKSGVA GGILLVVPNV MGMMCWSPPL DKMGNSVKGI HFCHDLVSLC NFHNYDNLRH FAKKLDPRRE GGDQRVKSVI NLLFAAYTGD VSALRRFALS AMDMEQRDYD SRTALHVAAA EGHVEVVKFL LEACKVNPFP KDRWNNTPMD EALHFGHHDV FKILQEYQVQ YTPQGDSDDG KENQTVHKNL DGLL
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
other info1 :
Species: Rattus norvegicus (Rat)
ncbi acc num :
NP_001103438.1
ncbi gb acc num :
NM_001109968.1
ncbi mol weight :
65,997 Da
ncbi pathways :
Alanine, Aspartate And Glutamate Metabolism Pathway (101111); Alanine, Aspartate And Glutamate Metabolism Pathway (100063); Arginine And Proline Metabolism Pathway (83349); Arginine And Proline Metabolism Pathway (323); D-Glutamine And D-glutamate Metabolism Pathway (83363); D-Glutamine And D-glutamate Metabolism Pathway (340); GABAergic Synapse Pathway (377244); GABAergic Synapse Pathway (377129); Glutamatergic Synapse Pathway (213815); Glutamatergic Synapse Pathway (213811)
ncbi summary :
catalyzes the conversion of L-glutamine and H2O to L-glutamate and NH3 in glutamine catabolism [RGD, Feb 2006]
uniprot summary :
glutaminase: Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity. Belongs to the glutaminase family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Amino Acid Metabolism - arginine and proline; Energy Metabolism - nitrogen; Hydrolase; Other Amino Acids Metabolism - D-Glutamine and D-glutamate; Amino Acid Metabolism - alanine, aspartate and glutamate; EC 3.5.1.2; Mitochondrial. Cellular Component: mitochondrion; cytosol. Molecular Function: protein binding; glutaminase activity. Biological Process: synaptic transmission; suckling behavior; glutamine catabolic process; neurological control of breathing; glutamate biosynthetic process; protein homotetramerization