catalog number :
MBS966979
products type :
Recombinant Protein
products full name :
Recombinant Human Utrophin (UTRN), partial
products short name :
Utrophin (UTRN), partial
products name syn :
Utrophin; Dystrophin-related protein 1; DRP-1
other names :
utrophin; Utrophin; utrophin; DRP-1; dystrophin-related protein 1; utrophin; Dystrophin-related protein 1; DRP-1
products gene name :
UTRN
products gene name syn :
UTRN; DMDL; DRP1
other gene names :
UTRN; UTRN; DRP; DMDL; DRP1; DMDL; DRP1; DRP-1
uniprot entry name :
UTRO_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
other info1 :
Species: Homo sapiens (Human)
ncbi acc num :
NP_009055.2
ncbi gb acc num :
NM_007124.2
ncbi mol weight :
155,026 Da
ncbi summary :
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
uniprot summary :
utrophin: May play a role in anchoring the cytoskeleton to the plasma membrane. Protein type: Motility/polarity/chemotaxis; Dystrophin complex. Chromosomal Location of Human Ortholog: 6q24. Cellular Component: nucleoplasm; dystrophin-associated glycoprotein complex; filopodium membrane; postsynaptic membrane; cytoskeleton; protein complex; membrane; cytoplasm; plasma membrane; cell junction; neuromuscular junction; filopodium. Molecular Function: integrin binding; protein binding; zinc ion binding; actin binding; protein kinase binding; vinculin binding. Biological Process: muscle development; muscle contraction; positive regulation of cell-matrix adhesion
size2 :
0.05 mg (Baculovirus)
size4 :
0.05 mg (Mammalian-Cell)