protein

Recombinant Human Transcobalamin-2 (TCN2)

MBS966735

0.5 mg (E-Coli)

1180 USD

Recombinant Protein

Recombinant Human Transcobalamin-2 (TCN2)

Transcobalamin-2 (TCN2)

Transcobalamin-2; TC-2; Transcobalamin II; TC II; TCII

transcobalamin-2 isoform 1; Transcobalamin-2; transcobalamin-2; macrocytic anemia; vitamin B12-binding protein 2; transcobalamin II; macrocytic anemia; transcobalamin II; Transcobalamin II; TC II; TCII

TCN2

TCN2; TC2

TCN2; TCN2; II; TC; TC2; TC-2; TCII; TC II; D22S676; D22S750; TC2; TC-2; TC II; TCII

TCO2_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

19-427

409

EM CEIPEMDSHL VEKLGQHLLP WMDRLSLEHL NPSIYVGLRL SSLQAGTKED LYLHSLKLGY QQCLLGSAFS EDDGDCQGKP SMGQLALYLL ALRANCEFVR GHKGDRLVSQ LKWFLEDEKR AIGHDHKGHP HTSYYQYGLG ILALCLHQKR VHDSVVDKLL YAVEPFHQGH HSVDTAAMAG LAFTCLKRSN FNPGRRQRIT MAIRTVREEI LKAQTPEGHF GNVYSTPLAL QFLMTSPMRG AELGTACLKA RVALLASLQD GAFQNALMIS QLLPVLNHKT YIDLIFPDCL APRVMLEPAA ETIPQTQEII SVTLQVLSLL PPYRQSISVL AGSTVEDVLK KAHELGGFTY ETQASLSGPY LTSVMGKAAG EREFWQLLRD PNTPLLQGIA DYRPKDGETI ELRLVSW

>90%

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Species: Homo sapiens (Human)

21071010

NP_000346.2

NM_000355.3

P20062

44,421 Da

Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway (833804); Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway (906000); Defective BTD Causes Biotidinase Deficiency Pathway (906015); Defective CD320 Causes Methylmalonic Aciduria Pathway (906012); Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway (906001); Defective GIF Causes Intrinsic Factor Deficiency Pathway (906004); Defective HLCS Causes Multiple Carboxylase Deficiency Pathway (906014); Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway (906003); Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway (906010); Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway (906009)

This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

TCN2: Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency). This results in various forms of anemia. Belongs to the eukaryotic cobalamin transport proteins family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 22q12.2. Cellular Component: lysosomal lumen; extracellular space; extracellular region; endosome. Molecular Function: metal ion binding; cobalamin binding. Biological Process: vitamin metabolic process; cobalamin metabolic process; cobalamin transport; cobalt ion transport; water-soluble vitamin metabolic process. Disease: Transcobalamin Ii Deficiency

0.5 mg (E-Coli)

1180 USD

0.05 mg (Baculovirus)

1180

0.5 mg (Yeast)

1400

0.05 mg (Mammalian-Cell)

1400

1 mg (E-Coli)

1900