catalog number :
MBS966725
products type :
Recombinant Protein
products full name :
Recombinant Mouse Retinal dehydrogenase 1
products short name :
Retinal dehydrogenase 1
products name syn :
ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic
other names :
retinal dehydrogenase 1; Retinal dehydrogenase 1; retinal dehydrogenase 1; aldehyde dehydrogenase family 1, subfamily A1; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic
products gene name :
Aldh1a1
other gene names :
Aldh1a1; Aldh1a1; E1; Ahd2; Ahd-2; Aldh1; Raldh1; Aldh1a2; Ahd-2; Ahd2; Aldh1; RALDH 1; RalDH1
uniprot entry name :
AL1A1_MOUSE
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
2-501
sequence :
SSPAQPAVPAPLADLKIQHTKIFINNEWHNSVSGKKFPV
LNPATEEVICHVEEGDKADVDKAVKAARQAFQIGSPWRT
MDASERGRLLNKLADLMERDRLLLATMEALNGGKVFANA
YLSDLGGCIKALKYCAGWADKIHGQTIPSDGDIFTYTRR
EPIGVCGQIIPWNFPMLMFIWKIGPALSCGNTVVVKPAE
QTPLTALHLASLIKEAGFPPGVVNIVPGYGPTAGAAISS
HMDVDKVAFTGSTQVGKLIKEAAGKSNLKRVTLELGGKS
PCIVFADADLDIAVEFAHHGVFYHQGQCCVAASRIFVEE
SVYDEFVKRSVERAKKYVLGNPLTPGINQGPQIDKEQHD
KILDLIESGKKEGAKLECGGGRWGNKGFFVQPTVFSNVT
DEMRIAKEEIFGPVQQIMKFKSVDDVIKRANNTTYGLAA
GLFTKDLDKAITVSSALQAGVVWVNCYMMLSAQCPFGGF
KMSGNGRELGEHGLYEYTELKTVAMKISQKNS
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
other info2 :
Species: Mus musculus (Mouse)
products categories :
Cancer
products description :
In addition to the activity on acetaldehyde and related substrates, is also involved in the oxidation of aldehydes derived from biogenic amines such as epinephrine and norepinephrine, as well as the aldehydes generated via lipid peroxidation. Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid
products references :
Isolation and characterization of a cytosolic aldehyde dehydrogenase-encoding cDNA from mouse liver."
Rongnoparut P., Weaver S.
Gene 101:261-265(1991)
ncbi acc num :
NP_038495.2
ncbi gb acc num :
NM_013467.3
ncbi mol weight :
56.34KD
ncbi pathways :
Amino Acid Metabolism Pathway (198416); Biological Oxidations Pathway (1324455); Dopminergic Neurogenesis Pathway (198342); Ethanol Oxidation Pathway (1324472); Fatty Acid Omega Oxidation Pathway (198425); Metabolic Pathways (132962); Metabolism Pathway (1324226); Phase 1 - Functionalization Of Compounds Pathway (1324456); RA Biosynthesis Pathway (1324789); Retinol Metabolism Pathway (198314)
uniprot summary :
ALDH1A1: Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid. Belongs to the aldehyde dehydrogenase family. Protein type: Apoptosis; EC 1.2.1.36; GAPs; GAPs, Ras; Cofactor and Vitamin Metabolism - retinol; Oxidoreductase. Cellular Component: cytoplasm; nucleus. Molecular Function: 3-chloroallyl aldehyde dehydrogenase activity; aldehyde dehydrogenase (NAD) activity; benzaldehyde dehydrogenase (NAD+) activity; identical protein binding; oxidoreductase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; retinal dehydrogenase activity. Biological Process: 9-cis-retinoic acid biosynthetic process; 9-cis-retinoic acid metabolic process; embryonic eye morphogenesis; metabolic process; optic cup morphogenesis involved in camera-type eye development; positive regulation of apoptosis; protein homotetramerization; response to drug; response to ethanol; response to oxidative stress; retinoic acid metabolic process; retinol metabolic process
size5 :
0.05 mg (Baculovirus)