catalog number :
MBS966605
products type :
Recombinant Protein
products full name :
Recombinant Macaca mulatta (Rhesus macaque) Interleukin-1 alpha (IL1A)
products short name :
(Rhesus macaque) Interleukin-1 alpha (IL1A)
products name syn :
Recombinant (Rhesus macaque) Interleukin-1 alpha (IL1A); Interleukin-1 alpha; IL-1 alpha; Hematopoietin-1
other names :
interleukin-1 alpha; Interleukin-1 alpha; interleukin-1 alpha; IL-1 alpha; hematopoietin-1; Hematopoietin-1
products gene name syn :
IL1A
other gene names :
IL1A; IL1A; IL-1 alpha
uniprot entry name :
IL1A_MACMU
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
113-271
sequence :
SAPFSFLSNMTYHFIRIIKHEFILNDTLNQTIIRANDQH
LTAAAIHNLDEAVKFDMGAYTSSKDDTKVPVILRISKTQ
LYVSAQDEDQPVLLKEMPEINKTITGSETNFLFFWETHG
TKNYFISVAHPNLFIATKHDNWVCLAKGLPSITDFQILE
NQA
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C. For extended storage, store at -20 or -80 degree C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
other info1 :
Species: Macaca mulatta (Rhesus macaque)
products description :
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
ncbi acc num :
NP_001036222.1
ncbi gb acc num :
NM_001042757.1
ncbi pathways :
Apoptosis Pathway (86730); Apoptosis Pathway (470); Cytokine-cytokine Receptor Interaction Pathway (86721); Cytokine-cytokine Receptor Interaction Pathway (460); Graft-versus-host Disease Pathway (86790); Graft-versus-host Disease Pathway (536); Hematopoietic Cell Lineage Pathway (86748); Hematopoietic Cell Lineage Pathway (489); Influenza A Pathway (217176); Influenza A Pathway (217150)
uniprot summary :
Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Subunit structure: Monomer. Subcellular location: Secreted. Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. Domain: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function. Sequence similarities: Belongs to the IL-1 family.